Manifold Bio · 12 hours ago
Senior Research Associate, Shuttled Oligo Therapeutics
Boston, MA
Full-time
Onsite
Senior Level
5+ years expManifold Bio is a dynamic biotech company focused on targeted biologics and innovative drug discovery. They are seeking a highly skilled Senior Research Associate to enhance their oligonucleotide shuttling capabilities, develop molecular assays, and contribute to the advancement of breakthrough therapeutics.
BiotechnologyHealth CarePharmaceuticalTherapeutics
Responsibilities
Prepare and analyze samples from in vitro and in vivo studies using a variety of biochemical and molecular biology techniques such as cell and tissue lysis, nucleic acid extraction, RT-qPCR, and SDS-PAGE
Support the development and optimization of assays and experimental methods for the purpose of evaluating oligonucleotide-based therapeutics in disease models
Design and perform cell-free and cell-based experiments to develop and implement novel assays and technologies
Author and maintain good written records of laboratory procedures and data, study protocols and other scientific documents. Present key findings at internal and external scientific meetings
Interact and communicate with supervisor, study leads and other team members
Support day-to-day laboratory tasks
Qualification
Required
B.S. or M.S. degree in Biology or related field with 5+ years of relevant laboratory research experience, or the equivalent experience obtained through working in a laboratory setting
Extensive experience and strong technical background with all aspects of molecular and cellular biology
Proficient in cell culture practices and methodologies, using a variety of mammalian cells (such as transformed cell lines and patient fibroblasts)
Nucleic acid methodologies and gene expression analysis including RNA/DNA isolation, RT-PCR, qPCR, agarose gel electrophoresis
Protein analysis methodologies including western blot, ELISA, Protein quantification assays
Familiarity with laboratory equipment, software and data analysis software
Excellent organization and communication skills and ability to collaborate effectively
Preferred
Experience with oligonucleotide therapeutics or antisense technologies (siRNA, antisense oligonucleotides)
Hands-on experience with flow cytometry and microscopy techniques
Company
Manifold Bio
Manifold Bio is building a protein barcoding platform to bring the power of multiplexed measurement.
11-50 employees
H1B Sponsorship
Manifold Bio has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2024 (1)
2023 (1)
2021 (1)
Funding
Current Stage
Early StageTotal Funding
$46.4MKey Investors
Amazon Web ServicesTriatomic CapitalPlayground Global
2025-10-08Non Equity Assistance· $1M
2022-06-13Series A· $40M
2020-09-11Seed· $5.4M
Leadership Team
Gleb Kuznetsov
Co-Founder and CEO
Pierce Ogden
Co-Founder, CTO and Board Director
Recent News
2025-12-17
Business Wire
2025-12-15
Business Wire
2025-12-13
Company data provided by crunchbase