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Valora Therapeutics, Inc. · 3 weeks ago

Principal Scientist/Senior Scientist, Immunology & Immuno-oncology

San Diego, CA

Full-time

Onsite

Senior Level

$140K/yr - $190K/yr

3+ years exp

Valora Therapeutics Inc. is a pre-clinical stage biopharmaceutical company revolutionizing antibody therapeutics. They are seeking a highly motivated Senior Scientist to join their R&D Operations team and advance next-generation antibody therapeutics through lab-based work in immunology and immune-oncology.

BiopharmaBiotechnologyClinical Trials

Responsibilities

Design and Execute Immunological Assays : Develop and optimize advanced in vitro and ex vivo assays to evaluate antibody mechanisms, immune modulation, and effector cell engagement

Data Analysis and Interpretation : Analyze complex datasets using tools like GraphPad Prism, FlowJo, etc., and present findings to cross-functional teams

Innovate and Hypothesize : Propose novel immunological targets and mechanisms to expand Valora’s R&D therapeutic development

Support Regulatory Milestones : Contribute to IND-enabling studies and filings

Collaborate : Work closely with interdisciplinary teams to drive project success

Qualification

ImmunologyAdvanced Flow CytometryImmunological AssaysAntibody EngineeringData AnalysisExperimental DesignCritical ThinkerCommunicatorCommittedPassionateSelf-DrivenCollaborativeAdaptable

Required

PhD in Immunology, Molecular Biology, or related field with 3-5+ years of relevant post-doctoral experience, or MS with 6-8+ years of experience in a biopharmaceutical setting

A proven track record of scientific productivity, including publications, patents, and presentations at scientific conferences in the areas of immunology and/or immuno-oncology

Advanced understanding of cellular and molecular immunology and Immuno-oncology, with expertise in methods to enhance innate and adaptive immunity in Immuno-oncology and reduce immune activity for autoimmunity

Expertise in immune cell phenotyping and functional analysis

Deep experience with human and mouse immune cell culture, co-culture in translational cellular systems

Expert-level proficiency in immunological assay design and execution with isolated primary human and mouse immune cells or PBMCs, including proficiency in cytotoxicity assays, cytokine detection (e.g., MSD, multiplex bead assays), and functional assays (ADCC, ADCP, CDC)

Familiarity with Fc engineering, bispecific/multispecific antibodies, or related technologies

Strong skills in statistical interpretation of scientific data

Ability to design well-controlled experiments, including power analysis for sample size determination

Experience with systematic reviews and critical evaluation of scientific literature

Excellent record-keeping using electronic lab notebooks (ELNs) and adherence to data integrity standards

Hypothesis-driven with creative problem-solving skills

Highly self-motivated, taking personal accountability for outcomes and demonstrating pride in delivering excellence in execution

Strong written and verbal skills to present complex data clearly

Thrives in cross-functional, fast-paced team environments

Quick to learn new techniques and concepts

Committed to scientific excellence and data integrity and committed for the success of the team and the company

Driven by scientific innovation and a desire to impact patients' lives