Kelly · 2 weeks ago
Scientist - Downstream Process Development
Gaithersburg, MD
Full-time
Onsite
Mid, Senior Level
$120K/yr - $130K/yrKelly Government Solutions is seeking a Scientist – Downstream Process Development to work on-site with the Vaccine Production Program at the National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH) in Gaithersburg, MD. The role involves developing and optimizing downstream purification processes for vaccine candidates, leading chromatography operations, and supporting technology transfer for clinical products.
OutsourcingProfessional Services
Responsibilities
Support the Purification group of the Vaccine Production Program (VPP) Labs of the Vaccine Research Center (VRC)
Develop downstream (purification) processes, under the supervision of a project lead scientist, for recombinant proteins, virus vaccines, and virus-like particles (VLP) that may be used as clinical vaccine candidates
Serve as a functional lead in chromatography process development unit operations
Provide critical process step assessment and experimental design to define optimal process parameters for chromatography unit operations
Train team members in large-scale unit operation such as AxiChrom column packing and Pilot-scale chromatography execution
Work independently and collaboratively within the purification group to design, develop and optimize chromatography and filtration step unit operations to support process development of clinical trial vaccine candidates and mAb products
Purify research-phase recombinant proteins, virus vaccines and/or virus-like particles in support of other groups at the VRC
Work to prepare necessary materials (buffers, packed columns, etc.) in support of downstream process activities
Perform protein/small molecule conjugation experiments to support method development or conjugate-based vaccine candidates
Support technology transfer of processes to VRC Pilot Plant for manufacture of clinical products including authoring process descriptions, reports, and on-floor support
Author training documents, process documents and summaries, instrument SOPs, technical reports, protocols, and other supporting documentation
Qualification
Required
Ph.D. in Bioengineering, Chemical Engineering, Biochemistry, or related scientific discipline
Extensive experience in recombinant protein purification development for GMP clinical-phase products
Familiarity with monoclonal antibody and multi-specific antibodies, recombinant protein vaccine and nanoparticles; mRNA and mRNA/LNP vaccines
Company
Kelly
We’ve been helping organizations find the people they need longer than any other company in the world.
Founded in 1946
10001+ employees
H1B Sponsorship
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Funding
Current Stage
Public CompanyTotal Funding
unknown1978-01-13IPO
Leadership Team
Chris Layden
Chief Executive Officer
N
Nicholas Zuhlke
Vice President, Controller, and Chief Accounting Officer
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