IRIS Kinetics · 1 month ago
Senior Scientist, Assay Development (Diagnostics & Biophysics)
Boston, MA
Full-time
Onsite
Senior Level
5+ years expIRIS Kinetics is pioneering a new class of label-free biosensing platforms for next-generation diagnostics and life sciences. They are seeking a Senior Scientist to lead assay development efforts for diagnostic and clinical applications, ensuring robust analytical performance and regulatory readiness.
Biotechnology
Responsibilities
Lead design and optimization of assays for detection of proteins, antibodies, nucleic acids, and small molecules across multiple applications
Develop and validate assay workflows using multiple methodologies including ELISA, MSD, BLI, SPR, and other immunoassay or biophysical platforms
Translate assay formats to the IRIS biosensor platform, establishing performance benchmarks for sensitivity, specificity, precision, and reproducibility
Design experiments to evaluate kinetics (kon, koff, KD), limits of detection, and matrix effects
Oversee conjugation, immobilization, and surface functionalization/spotting strategies for antibodies, antigens, and nucleic acids
Develop analytical verification and validation plans aligned with regulatory and FDA submission requirements
Collaborate closely with engineering to integrate assay workflows into hardware and software design
Mentor and guide junior scientists and associates, fostering a culture of technical excellence and innovation
Contribute to publications, grant applications, and investor-facing technical documentation supporting product and fundraising milestones
Qualification
Required
Ph.D. or M.S. in Biochemistry, Molecular Biology, Biophysics, Biomedical Engineering, or related field
5+ years of industry experience developing assays for IVD or life science platforms
Proven expertise in immunoassay development and characterization of antigen–antibody interactions
Hands-on experience with one or more label-free biosensing technologies (BLI, SPR, QCM) and conventional assays (ELISA, MSD, etc.)
Strong understanding of conjugation and surface functionalization chemistry (protein coupling, spotting, immobilization)
Familiarity with diagnostic product development, including verification/validation and regulatory submission (FDA, CLIA, or CE-IVD)
Demonstrated ability to design and execute experiments independently, analyze data, and communicate results clearly
Preferred
Experience with multiplexed assays and biosensor-based diagnostic products
Prior involvement in FDA submission or regulatory documentation for diagnostic assays
Leadership experience mentoring teams and cross-functional collaboration in fast-paced environments
Ability to balance high-level strategy with hands-on experimental work
Benefits
Competitive compensation
Benefits
Growth opportunity toward leadership roles
Company
IRIS Kinetics
At iRiS Kinetics, we are pioneering the future of molecular interaction analysis with instrumentation designed for the label-free detection of biomolecular binding.
2-10 employees
Funding
Current Stage
Early StageLeadership Team
Selim Unlu
Founder and CEO
Claude Dufresne
Chief Commercial Officer (CCO)
Company data provided by crunchbase