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Pfizer · 5 hours ago

Senior Principal Scientist, Pre-Formulation and Materials Science

La Jolla, CA

Full-time

Onsite

Senior Level, Lead/Staff

$121K/yr - $201K/yr

10+ years exp

Pfizer is a leading biopharmaceutical company, and they are seeking a Senior Principal Scientist to support early-stage drug and drug product design. The role involves providing scientific leadership and direction on molecular design, dosage form design, and biopharmaceutics aspects of drug development.

BiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine

No H1B

U.S. Citizen Only

Responsibilities

Will provide scientific advances, leadership, and strategic direction for the fundamental understanding of key connectivity of molecular structure, solution and diffusion behavior and permeation characteristics to enable optimal drug formulation and drug delivery systems design

Integrates pharmaceutics, physical organic chemistry, biophysical chemistry, supramolecular chemistry, materials science, and fundamental biopharmaceutics principles into drug candidate screening and design, formulation design, solid form strategy, and ultimately project direction

Teach and mentor colleagues across the Pfizer organization

Cultivates sustainable and effective relationships with internal partners and stakeholders, i.e., partner lines in Medicinal Design, Pharmaceutical Sciences Small Molecule (PSSM), Clinical Pharmacology , Drug Safety (DSRD), relevant Research Units, and Pharmacokinetics, Dynamics, and Metabolism (PDM)

Advances scientific research and expands capability in the areas of molecular design-drug delivery, materials science, early biopharmaceutics, and drug formulation

Qualification

Molecular designDrug delivery strategyBiopharmaceutics understandingMaterials science characterizationCrystallization principlesPredictive modeling toolsPharmacokineticsLeadershipCommunication skillsTeam collaborationOrganizational skills

Required

PhD in Pharmaceutics, Pharmaceutical Sciences, Materials Science, Physical Chemistry, Physical Organic Chemistry, Biophysical Chemistry or related discipline with 10+ years relevant experience in drug delivery, or BS/MS in Pharmaceutics, Pharmaceutical Sciences, Materials Science, Physical Chemistry, Physical Organic Chemistry, Biophysical Chemistry or related discipline with a minimum of 10-12 years relevant pharmaceutics industry experience in small molecule drug product design

Knowledge in biology/pharmacology/drug discovery /drug delivery up to Proof of Concept (POC) studies

Small molecule Formulation and/or early Biopharmaceutics, Materials Science, or Pharmacokinetics background, and a strong record of scientific achievement

Experience in using and interpreting biophysical modeling, physicochemical (solubility & dissolution) and biological (passive, transporter mediated, efflux) transport phenomena, design, interpretation, and use of in vitro experiments, or in vivo/in vitro drug metabolism studies, and interpretation of pre-clinical exposure data for the design and selection of new small molecule drug candidates and drug delivery systems

A strong interest and motivation to learn and implement new technologies and concepts

A strong interest in leadership

Extensive practical experience working within cross-disciplinary teams and achieving results in a matrix environment

Excellent organizational and communication (oral and written) skills

The ability to work independently, as well as collaboratively