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Arc Institute · 2 weeks ago

Scientist, Functional Genomics, Konermann Lab

Palo Alto, CA

Full-time

Onsite

New Grad, Entry, Mid Level

$121K/yr - $150K/yr

0+ years exp

Arc Institute is a new scientific institution focused on understanding and treating complex human diseases. The Konermann Lab is seeking a Scientist to lead and collaborate on projects in functional genomics and neurobiology, applying advanced technologies to decipher biological processes in neurons and other cell types.

BiotechnologyNon ProfitTraining

H1B Sponsor Likely

Responsibilities

Collaborate with neurobiologists to implement functional genomics assays (arrayed and pooled) in human iPSC-derived neurons, microglia and multi-cellular stem cell derived brain models

Serve as the technical expert in the design, execution, and analysis of functional genomic screens

Develop and optimize novel screening assays and readouts suitable for neuronal/glial phenotypes

Perform cell culture, differentiation, and genome engineering of human ESC/iPSC and/or immune cell types

Analyze multi-omic datasets and collaborate with computational scientists to derive insightful conclusions as well as generate new testable hypotheses

Present findings at internal meetings and external conferences, and contribute to the preparation of high-impact manuscripts

Qualification

Functional genomicsCRISPR screeningCell cultureMolecular biology techniquesData analysisSingle-cell RNA-seqBioinformaticsCommunicationCollaborative mindsetMentoring

Required

PhD in Molecular Biology, Bioengineering, Genetics, or a related field

0-3 years of post-PhD research experience (industry or academia)

Strong hands-on experience with mammalian cell culture and molecular biology techniques (cloning, library preparation, etc.)

Deep expertise in functional genomics, specifically with CRISPR screening technologies (pooled or arrayed) including library design, library cloning, delivery of gene editors, screen design, screen execution and screen analysis

Strong critical thinking and data analysis skills, with the ability to troubleshoot complex experimental protocols

Excellent written and verbal communication skills, with a track record of peer-reviewed publications or preprints

A collaborative mindset and enthusiasm for mentoring and working within a cross-functional team

Preferred

Experience with single-cell RNA-seq and single-cell genomics technologies (e.g. 10X Genomics, Perturb-seq/CROP-seq or similar)

Experience with live-cell microscopy, optical pooled screening and/or multiplexed proteomic readouts (e.g. CITE-seq, Olink or similar)

Experience working with human iPSCs and differentiation procedures

Background in neurobiology/neurodegenerative disorders

Proficient in bioinformatics/data analysis of large datasets (using Python, R etc)

Benefits

Annual discretionary bonus

Company

Arc Institute

Arc Institute is a biomedical science and research technology company.

Founded in 2021

Palo Alto, California, USA

51-200 employees

https://arcinstitute.org

H1B Sponsorship

Arc Institute has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

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Trends of Total Sponsorships

2025 (24)

2024 (13)

2023 (3)