Incyte · 3 days ago
Sr. Director, Computational Biology
Wilmington, DE
Full-time
Onsite
Director/Executive
10+ years expIncyte is a biopharmaceutical company focused on developing novel medicines for oncology and inflammation. The Senior Director, Computational Biology, will lead a team of computational biologists to drive biological insights across the R&D pipeline, collaborating with various teams to shape scientific and analytic strategies for transformative therapies.
BiotechnologyHealth CareMedicalMedical DevicePharmaceutical
Responsibilities
Lead and grow the Computational Biology function, setting scientific direction, establishing best practices, and ensuring high-quality, innovative analyses that advance portfolio decision-making
Partner with discovery and translational program teams to design computational strategies for target ID, MOA elucidation, patient stratification, and biomarker hypothesis development
Serve as a thought leader in genomics, multi-omics integration, and biological modeling; bring forward emerging technologies, platforms, and analytical approaches
Define the strategic vision for the use of AI/ML approaches in biological data analysis, including opportunities for advanced modeling, multimodal data integration, and predictive analytics across discovery and translational programs
Drive target identification and validation efforts by integrating public and private multi-omics datasets, functional genomics screens, pathway modeling, and literature/knowledge graph analyses to prioritize high-value therapeutic hypotheses
Oversee analysis, interpretation, and integration of diverse data types (genomics, transcriptomics, single-cell, proteomics, real-world data, etc.) to generate actionable insights for research and clinical programs
Partner with clinical and translational teams to drive reverse translation from clinical studies, including identifying factors underlying patient response, resistance mechanisms, and biomarker refinement
Guide the application of ML in biomarker discovery, including feature selection, model validation, and biological interpretation in support of translational hypotheses
Collaborate with clinical teams, regulatory, and external partners to support biomarker plans, CDx-relevant analytics, and data packages for regulatory submissions as needed, and contribute to decision-making
Build strong partnerships across R&D to ensure seamless integration of computational biology, data science, and experimental teams; advocate for AI/ML literacy and responsible use across stakeholder groups
Represent Computational Biology in internal committees and external collaborations; communicate complex outputs in clear, biologically meaningful terms to audiences ranging from bench scientists to executives
Mentor team members in computational biology and AI/ML approaches; support career development and recruitment of talent with emerging skills in modern computational methods
Qualification
Required
Ph.D. in Computational Biology, Bioinformatics, Molecular Biology, Cancer Biology, Genetics, or a related field
10+ years of industry or academic experience with a strong record of scientific accomplishment in computational biology, oncology/immuno-oncology, or translational science
5+ years of leadership experience
Demonstrated success in leading scientific teams and delivering impactful insights into drug discovery and development programs
Deep expertise in bioinformatics, multi-omics analysis, and biological interpretation
Strong familiarity with biomarker discovery, translational science, and clinical genomics workflows
Experience with modern AI/ML approaches for biological data required
High emotional intelligence and a collaborative leadership style; proven ability to build trust and work seamlessly across diverse functional groups
Ability to manage and prioritize multiple projects in a fast-paced R&D environment
Passion for understanding human biology and advancing novel therapeutics
Innovative mindset with a strong drive to push scientific boundaries
Company
Incyte
Incyte is a drug discovery and development company which hopes to build a proprietary product pipeline of novel small molecule drugs.
1001-5000 employees
H1B Sponsorship
Incyte has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (37)
2024 (34)
2023 (32)
2022 (39)
2021 (36)
2020 (24)
Funding
Current Stage
Public CompanyTotal Funding
unknown1996-01-16IPO
Leadership Team
Bill Meury
President & CEO
Jim Lee
Group Vice President, Head Inflammation and AutoImmunity Group
Recent News
2026-01-06
2026-01-05
Company data provided by crunchbase