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Tango Therapeutics · 3 hours ago

Vice President, Clinical Development

Boston, MA

Full-time

Onsite

Director/Executive

$311K/yr - $467K/yr

15+ years exp

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. They are seeking an experienced oncologist to serve as Vice President Clinical Development, where the successful candidate will drive clinical development strategy and execution for PRMT5 programs in development for MTAP-deleted cancers.

BiotechnologyHealth CareMedicalTherapeutics

Responsibilities

Drive pivotal phase III programs for TNG462 by leading protocol development, amendments, and operational execution, while partnering with the Head of Clinical Development on strategy and key decisions

Work cross-functionally with Clinical Operations, Regulatory, Medical Affairs, Biostatistics, and others; partner with Medical Affairs on publications, abstracts, and investigator meetings; represent Clinical Development in industry partnerships; and design and initiate study protocols and amendments in compliance with GCP/ICH and regulatory requirements

Directly manage clinical scientists supporting the PRMT5 program

Provide mentorship and development opportunities for emerging clinical leaders

Foster a culture of scientific rigor, operational excellence, and collaboration

Provide strategic input into regulatory meeting planning, preparation, and slide deck development

Lead authorship and provide close oversight of regulatory documents including protocols, INDs, briefing documents, and responses to health authority questions

Support the development and compilation of regulatory filings including INDs, CTAs, and NDAs

Partner with Project Management on clinical governance meeting agendas and cross-functional alignment

Establish and drive operational improvement initiatives

Work closely with clinical teams to support patient recruitment strategies and maintain strong relationships with Principal Investigators

Monitor adherence to protocols and ensure consistency in quality standards across all program activities

Build and maintain relationships with key investigators, thought leaders, and clinical trial sites

Act as liaison between company and clinical investigators

Represent PRMT5 clinical development at scientific conferences and investigator meetings

Review/co-author medical publications emerging from clinical trial results

Qualification

MD degreeClinical development experienceIND filingsScientific writingICH-GCP knowledgeOncology expertiseRegulatory submissionTeam managementLeadership skillsCommunication skillsProblem-solving

Required

MD degree with board certification or eligibility in medical oncology or hematology-oncology

Minimum 15+ years of clinical development experience in oncology in the biotechnology or pharmaceutical industry, with at least 5 years in late-stage (Phase 2/3) programs

Hands-on experience in the design, execution, and reporting of clinical trials in oncology, evaluating small molecule targeted agents and/or immunological therapies

Direct experience with IND filings required

Demonstrated experience leading global clinical programs from protocol design through regulatory submission

Strong scientific writing skills with proven track record of regulatory document authorship

Experience managing and mentoring clinical development teams

Deep understanding of ICH-GCP, FDA regulations, and global regulatory requirements

Effective leadership, people management, team-oriented and results-oriented style with strong interpersonal, verbal, written, communication, and presentation skills

Flexible, creative, optimistic, and resourceful style and attitude