Exelixis · 1 day ago
Scientist III - Bioconjugation (ADC) Process Development
Alameda, CA
Full-time
Onsite
Mid Level
$90K/yr - $128K/yr
3+ years expExelixis is a biotechnology company focused on developing innovative therapies for cancer patients. The Scientist III, Bioconjugation (ADC) Process Development, will be responsible for the development of scalable and robust downstream ADC processes and support technology transfer efforts leading to clinical GMP manufacturing of ADCs.
BiotechnologyHealth CarePharmaceutical
Responsibilities
Technical knowledge at design, execution and data interpretation of experiments related to development, optimization, and scale-up of biologics with a focus on ADC Bioconjugation and Purification processes
Develop Subject Matter Expertise in bioconjugation (ADC) process development and manufacturing in support of CMC activities
Work closely with research function to understand relevant conjugation chemistries and transition bioconjugation process from research to CMC development
The ability to identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding
Experience in applying DOE and other advanced statistical techniques to design experiments (DoE) related to process development
Familiarity with authoring high-quality documents, including technical reports, SOPs, experimental protocols, drafting tech transfer related documents (process description, process flow diagrams, tech transfer reports, etc.) reviewing batch records, and sampling plans
The ability to contribute to MFG floor activities and provide scale up, technical support and troubleshooting to MFG groups at clinical and commercial manufacturing sites
Demonstrated ability to work effectively with CDMOs, is a plus
A familiarity with critically relevant areas such as analytical, formulation, and the general CMC scope for biologics is preferred
Qualification
Required
Bachelor's degree in chemistry, biochemistry, pharmaceutical sciences, chemical engineering or related field and a minimum of 3 years of relevant industry experience; or
Master's degree in chemistry, biochemistry, pharmaceutical sciences, chemical engineering or related field and a minimum of 1 year of relevant industry experience; or
Equivalent combination of education and experience
Technical knowledge at design, execution and data interpretation of experiments related to development, optimization, and scale-up of biologics with a focus on ADC Bioconjugation and Purification processes
Develop Subject Matter Expertise in bioconjugation (ADC) process development and manufacturing in support of CMC activities
Work closely with research function to understand relevant conjugation chemistries and transition bioconjugation process from research to CMC development
The ability to identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding
Experience in applying DOE and other advanced statistical techniques to design experiments (DoE) related to process development
Familiarity with authoring high-quality documents, including technical reports, SOPs, experimental protocols, drafting tech transfer related documents (process description, process flow diagrams, tech transfer reports, etc.) reviewing batch records, and sampling plans
The ability to contribute to MFG floor activities and provide scale up, technical support and troubleshooting to MFG groups at clinical and commercial manufacturing sites
Ability to collaborate with cross-functional teams, both internally and with external CDMOs and partners
Ability to multi-task in a fast-paced dynamic environment while delivering high-quality work
Self-motivated, accountable, and inquisitive attitude with excellent interpersonal, presentation, and written communication skills
Creative thinker and complex problem solver with strong attention to details
A demonstrated ability to work both independently and as a member of local and global teams
Preferred
Direct experience designing and implementing experiments to evaluate bioconjugation processes, including ADCs, is preferred
Hands-on experience with ADC chemistry, reaction processes and purification methods (i.e. Tangential flow filtration, chromatography, etc.)
Demonstrated experience and working knowledge of technical transfer for Biologics manufacturing (bioconjugations), is a plus
Additional experience with the development and manufacturing of mAbs, bispecifics and/or linker-toxins used in ADC production, and familiarity with analytical methods, is a plus
A familiarity with critically relevant areas such as analytical, formulation, and the general CMC scope for biologics is preferred
Benefits
401k plan with generous company contributions
Group medical, dental and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Sales-based incentive plan
Opportunity to purchase company stock
Receive long-term incentives
15 accrued vacation days in their first year
17 paid holidays including a company-wide winter shutdown in December
Up to 10 sick days throughout the calendar year
Company
Exelixis
Exelixis works is focused on discovering, developing and commercializing therapies for the treatment of cancer and other serious diseases.
1001-5000 employees
H1B Sponsorship
Exelixis has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (39)
2024 (25)
2023 (25)
2022 (28)
2021 (29)
2020 (15)
Funding
Current Stage
Public CompanyTotal Funding
$514MKey Investors
Deerfield
2015-07-23Post Ipo Equity· $135M
2012-02-16Post Ipo Equity· $65M
2010-06-03Post Ipo Debt· $160M
Leadership Team
Michael Morrissey
President and CEO
Christopher Senner
Executive Vice President and CFO
Recent News
Investor's Business Daily
2025-12-22
2025-12-13
2025-12-12
Company data provided by crunchbase