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Denali Therapeutics · 5 hours ago

Associate Scientist, Bioassay Development

South San Francisco, CA

Full-time

Onsite

Mid Level

$107K/yr - $131K/yr

3+ years exp

Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases. The Associate Scientist will develop, optimize, and establish potency assays for large molecule biotherapeutics, supporting various projects and ensuring quality control standards are met.

BiotechnologyGeneticsHealth DiagnosticsTherapeutics

H1B Sponsor Likely

Responsibilities

Independently perform bioassays to support cell and plate-based (ELISA, ENZYME ACTIVITY) development for late stage molecule

Assist in the development, optimization, and qualification of assays for product release and stability testing as well as characterization of biological activity

Support study sample testing, analysis and maintain complete and accurate records and contribute to continuing process improvement

Evaluate, characterize, and document critical reagents to meet QC standards

Coordinate parallel tasks across multiple projects and prioritize deliverables to meet departmental and organizational goals

Promote innovation and explore novel analytical techniques or technology

Qualification

Bioassay developmentCell-based assaysELISAData analysisAseptic techniqueCommunicationCritical thinkingOrganizational skillsProblem-solvingDetail-oriented

Required

BS with 3+ years of industry experience or an MS 1+ years relevant experience in the industry

Experience in developing and optimizing bioassays using cell based assay, ELISA, HTRF, Enzyme activity, Enzyme Kinetics, Octet is required

Proficient in aseptic technique, mammalian and primary cell handling

Proficient in data analysis with Excel and statistical tools such as GraphPad Prism, SoftMax Pro, and PLA 3.0

Familiar with electronic notebooks and documentation workflows

Ability to balance competing priorities and thrive in a dynamic, fast-paced environment

Excellent laboratory, critical thinking, scientific problem-solving, and organizational skills

Excellent oral and written communication skills

Motivated, detail-oriented, naturally curious individual with a creative approach to scientific problem solving and a burning desire to help patients with neurodegenerative diseases

Benefits

401k

Healthcare coverage

ESPP

A broad range of other benefits

Company

Denali Therapeutics

Denali Therapeutics is dedicated to defeating neurodegenerative diseases to deliver safe and effective medicines to patients and families.

Founded in 2013

San Francisco, California, USA

501-1000 employees

https://www.denalitherapeutics.com

H1B Sponsorship

Denali Therapeutics has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (11)

2024 (14)

2023 (7)

2022 (6)

2021 (5)

2020 (1)

Funding

Current Stage

Public Company

Total Funding

$1.32B

Key Investors

Royalty PharmaBaillie Gifford

2025-12-04Post Ipo Debt· $200M

2024-02-27Post Ipo Equity· $500M

2022-10-19Post Ipo Equity· $275M

Leadership Team

Ryan Watts

CEO

Peter Chin

Sr. Vice President & Head of Late-Stage Clinical Development and Medical Affairs

Recent News

Labiotech UG

The biggest biotech funding rounds in December 2025

2026-01-11

GlobeNewswire

Denali Therapeutics Announces Key Anticipated Milestones and Priorities for 2026 Including Commercial Launch of Tividenofusp Alfa for Hunter Syndrome

2026-01-06

Longevity.Technology

NEJM publishes Phase 1/2 study of Denali’s tividenofusp alfa in Hunter syndrome

2026-01-03

Company data provided by crunchbase