Johnson & Johnson · 23 hours ago
Senior Principal Data Scientist, Real World Evidence (RWE)
San Diego, CA
Full-time
Hybrid
Senior Level, Lead/Staff
$137K/yr - $236K/yr
4+ years expJohnson & Johnson is a leader in healthcare innovation dedicated to improving health outcomes. The Senior Principal Data Scientist will lead RWE projects, develop evidence solutions, and collaborate with multidisciplinary teams to enhance clinical development in Oncology, Immunology, or Neuroscience.
Hospital & Health Care
Responsibilities
Be a hands-on technical leader, leading a portfolio of RWE projects while developing best practices and common technical tools
Support the development of the R&D RWE strategy for the generation and utilization of RWE for our key pipeline assets
End-to-end expertise in RWE studies (external control arm, novel endpoints, trial design optimization) including conceptualizing research questions, data feasibility, study design, analysis, programming, and interpretation
Assess treatment patterns and unmet needs using RWE to inform asset positioning
Ensure RWE generation aligned with regulatory requirements and scientific standards
Identify evidence opportunities and develop innovative evidence programs to support early development, registration, and post-marketing phases
Shape the selection of real-world data sources, establish data quality standards, and ensure data robustness and relevance for clinical research
Lead and develop junior researchers and programmers in executing strategies to develop RWE from concept through publication
Support regulatory interactions and meetings with scientific data packages and expertise
Qualification
Required
A Ph.D. degree, or master's degree in a quantitative field (e.g., epidemiology, biostatistics, statistics, or similar)
Relevant experience (4+ years for Ph.D., 6+ years for a master's) within biopharma companies, RWE consulting firms, or other relevant healthcare industries
Extensive hands-on experience with data engineering and exploratory data analysis, statistical modeling, time-to-event analyses, comparative effectiveness analyses, causal inference methods
Demonstrated expertise with multiple real-world data sources
Expert proficiency in R and SQL
Familiarity with data structure and programming of clinical trial data
Strong communication and influencing skills, capable of inspiring teams and driving cross-functional alignment
Highly motivated and intellectually curious, with strong executional rigor and a passion for solving complex challenges
Preferred
Familiarity with drug discovery and the clinical development process
Expertise in oncology, Immunology or Neuroscience drug development
Experience in regulatory-grade evidence, communicating and responding to agency reviews and comments
Benefits
Medical
Dental
Vision
Life insurance
Short- and long-term disability
Business accident insurance
Group legal insurance
Consolidated retirement plan (pension)
Savings plan (401(k))
Vacation – up to 120 hours per calendar year
Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year
Holiday pay, including Floating Holidays – up to 13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Company
Johnson & Johnson
At Johnson & Johnson, we believe health is everything.
10001+ employees
H1B Sponsorship
Johnson & Johnson has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (48)
2024 (56)
2023 (58)
2022 (59)
2021 (44)
2020 (27)
Funding
Current Stage
Late StageLeadership Team
Alex Gorsky
Former Chairman and CEO, Johnson & Johnson
Joaquin Duato
Chairman of the Board and Chief Executive Officer
Recent News
2025-10-07
2025-10-07
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