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Amide Technologies · 3 weeks ago

Scientist, Peptide Purification

Waltham, MA

Full-time

Onsite

Mid, Senior Level

2+ years exp

Amide Technologies is a Massachusetts-based biotech company focused on synthesizing peptides and proteins that are difficult to obtain through existing means. They are seeking a Scientist or Senior Scientist in Peptide Purification to purify and analyze synthetic peptides, collaborate with various teams, and drive innovation in purification techniques.

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Responsibilities

Purify and analyze synthetic peptides and proteins (1-15 kDa, with a variety of chemical modifications such as fatty acid chains, biotinylation, fluorophores, disulfides, small molecule conjugates etc.) using RP-HPLC and LCMS instrumentation

Collaborate closely with the synthesis team to diagnose complicated crude mixtures, identify synthetic byproducts, and develop strategies to isolate difficult impurities

Troubleshoot and optimize challenging purifications, including sequences with poor solubility, aggregation tendencies, or unusual chromatographic behavior

Optimize and accelerate chromatographic methods for purifying a wide range of polyamides with differing properties

Drive innovation in purification automation, including improved fraction handling, screening workflows, and data management

Contribute to ongoing innovation within the company through the introduction of new chromatography trends, technologies, and resin/column chemistries

Meticulously record, analyze, and organize data for use in presentations to the purification team and leadership teams