Twist Bioscience · 2 weeks ago
Scientist / Sr Scientist / Staff Scientist (NGS Applications)
South San Francisco, CA
Full-time
Onsite
Mid, Senior Level, Lead/Staff
$127K/yr - $200K/yr
0+ years expTwist Bioscience is a company focused on synthesizing genes from scratch to revolutionize genomics. They are seeking a highly motivated Scientist/Sr Scientist/Staff Scientist to join their Next-Generation Sequencing (NGS) product development team, where the successful candidate will evaluate, optimize, and support NGS solutions, contributing to product innovation and scientific communication.
B2BBiotechnologyChemicalHealth CareLife Science
Responsibilities
Provide Molecular Biology Expertise: Apply advanced molecular biology techniques to develop, optimize, and troubleshoot complex NGS workflows, with a focus on maximizing data quality and experimental efficiency
Lead NGS Tools Evaluation & Optimization: Design and execute rigorous experimental plans to test and optimize various NGS library preparation kits and sequencing platforms (e.g., Illumina, PacBio, Oxford Nanopore) with our existing and prospective product lines, ensuring optimal performance and competitive positioning
Customer-Centric Support & Collateral Generation: Contribute to essential post-launch product support with experiments analyzing customer samples, troubleshooting issues, and author high-impact collateral (white papers, technical notes, application briefs) that provide guidance for our users
Product Development Input: Actively participate in the design, development, and validation of novel NGS library preparation kits and applications, offering critical experimental data and technical recommendations
Data Analysis & Visualization: Perform initial assessment of NGS data (e.g., QC metrics, alignment, variant calling outcomes), employing computational tools to visualize and present complex data in a clear and concise manner
Rigorously document experimental procedures, results, and conclusions, ensuring data integrity and reproducibility across all projects
New Technology Implementation: Evaluate and integrate emerging NGS technologies and methodologies to continuously enhance our capabilities and keep our product offerings at the forefront of genomic research
Qualification
Required
Experience in Molecular Biology, Genomics, Biochemistry, or combination of closely-related field and experience
Scientist Requires a PhD and 0-2 years of previous professional experience; or a master's degree and 3-5 years of work experience
Sr Scientist Requires a Ph.D. and 2-5 years of professional experience (postdoc may count); or a master's degree and 5-7 years of work experience
Staff Scientist Requires a Ph.D. and 5-8 years of professional experience (postdoc may count); or a master's degree and 7 years of work experience
Strong background in general Molecular Biology techniques including mechanical or enzymatic library preparations, NGS library analysis (e.g. Agilent BioAnalyzer and/or TapeStation assays), DNA purification (e.g. SPRI purification), DNA quantification (e.g. Qubit assays), and PCR/qPCR
Must have direct lab experience and background with Next Generation Sequencing Technology Platforms (e.g., Illumina, PacBio, Ion Torrent, Nanopore etc.), including corresponding sample preparation techniques, preparation and management of outputs from sequencing runs, and day-to-day operation and troubleshooting of physical equipment
Must have direct lab experience with NGS Target Enrichment Workflows
Demonstrated ability to analyze NGS data output, interpret results, and utilize bioinformatics tools for data visualization and presentation (e.g., R, Python, Jupyter notebooks, matplotlib, ggplot2)
Solid publication record (peer-reviewed articles, patents, or significant contributions to technical reports) and experience writing technical documentation, white papers, or application notes for scientific products
Strong analytical and problem-solving skills, with a methodical approach to experimental design and data interpretation
Dynamic interpersonal skills, with a collaborative and respectful approach to teamwork
Comfortable and effective working in a fast-paced, R&D and customer-facing environment, capable of managing multiple projects simultaneously
Preferred
Hands-on experience with specific NGS applications such as RNA-Seq, ChIP-Seq, ATAC-Seq, metagenomics, single-cell sequencing, or targeted sequencing
Direct experience with automation platforms for high-throughput library preparation
Familiarity with regulatory requirements or quality control standards in a diagnostic or clinical genomics setting
Prior experience in a customer-facing scientific support or applications role
Benefits
Bonus
Equity
Generous benefits package
Company
Twist Bioscience
Twist Bioscience is a biotechnology company that offers synthetic DNA solutions, gene synthesis, and variant libraries.
501-1000 employees
H1B Sponsorship
Twist Bioscience has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (18)
2024 (14)
2023 (22)
2022 (19)
2021 (4)
2020 (6)
Funding
Current Stage
Public CompanyTotal Funding
$553.11MKey Investors
Capital World InvestorsBiomatics Capital PartnersIllumina
2022-02-09Post Ipo Equity· $250M
2020-01-27Post Ipo Equity· $50M
2018-10-30IPO
Leadership Team
Emily Leproust
CEO
Siyuan Chen
Chief Technology Officer
Recent News
Genetic Engineering News
2026-01-17
2026-01-16
Company data provided by crunchbase