SRT Therapeutics Inc. · 3 weeks ago
Scientist / Senior Scientist, Computational Biology
San Diego, CA
Full-time
Onsite
Mid, Senior Level
$120K/yr - $190K/yr
2+ years expSRT Therapeutics is a San Diego-based biotech company focused on enhancing patient care through precision medicine strategies. They are seeking a Senior Scientist in Computational Biology to support the development of data-driven strategies for identifying and validating biomarkers in inflammatory diseases.
BiopharmaBiotechnologyHealth CareWellness
Responsibilities
Develop and implement integrative computational frameworks combining statistical modeling, machine learning, and systems biology to identify robust, reproducible biomarkers and therapeutic targets
Perform rigorous statistical and computational analyses integrating diverse omics datasets, including genomics, transcriptomics, proteomics, single-cell, and spatial sequencing data
Develop scalable and reproducible computational pipelines for biological data processing, harmonization, and cross modalities integration
Develop and implement novel, genomics-based patient segmentation strategies to support precision medicine
Build, train, and tune machine learning and deep learning models using large-scale public and proprietary datasets to predict target activity, patient response, and inform mechanism of action
Support and collaborate with a multidisciplinary team of bioinformaticians, data scientists, geneticists, and bench scientists to translate •in silico• findings
Proactively identify, evaluate, analyze, and integrate mission-relevant genomic datasets into the company's knowledge base
Clearly and rapidly communicate findings, methodologies, and results to both technical and non-technical stakeholders
Contribute to building our computational infrastructure, implementing coding and architecture best practices (Python, R, AWS, git, etc.)
Document and maintain computational workflows for reproducibility, including version control (git), containerization (Docker), and workflow automation (Snakemake/Nextflow)
Qualification
Required
PhD or equivalent experience in Computational Biology, Bioinformatics, Data Science, Genetics, or a related field
2-5 years' post-doctoral experience in drug development
Demonstrated success in target and/or biomarker identification and validation in a drug discovery setting using multimodal human datasets (e.g., genomics, transcriptomics, proteomics, imaging, and clinical data)
Strong hands-on experience in the quality control, processing, and analysis of a wide range of genetic and genomic data types including bulk and multi-modal single cell RNAseq, SNP arrays, and proteomics
Deep understanding of gene networks, pathway analysis, and systems-level data interpretation
Proven expertise in applying machine and deep learning for biological prediction, classification, or patient stratification
High proficiency in Python and R, with a strong command of coding best practices and version control
Experience with cloud computing environments (preferably AWS)
Proven ability to work collaboratively in a fast-paced, matrixed team
Preferred
Start-up experience is preferred
Experience in computer vision and AI for histopathology (e.g., image QC/normalization, cell/tissue segmentation, CNNs, vision transformers)
Experience training, fine-tuning, or applying biological foundation models
Benefits
Health, dental, and vision insurance
Paid time off and company holidays
Bonus & Equity eligibility
Company
SRT Therapeutics Inc.
SRT Therapeutics is a San Diego-based biotech company established in 2024 by the founders of Prometheus Biosciences, Steph Targan, MD (Cedars Sinai), Janine Bilsborough, Ph.D.
11-50 employees
Funding
Current Stage
Early StageTotal Funding
$47.4M2025-08-13Undisclosed· $47.4M
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