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Genentech · 1 day ago

Engineering Team Lead - AI for Drug Discovery

South San Francisco, CA

Full-time

Onsite

Lead/Staff

$197K/yr - $366K/yr

12+ years exp

Genentech is a leading biotechnology company focused on innovative drug discovery. They are seeking an Engineering Team Lead to manage the Therapeutic Molecule Registration team, driving the development of a next-generation system to support AI-driven drug discovery workflows.

BiotechnologyLife ScienceManufacturing

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Lead and mentor an existing team of software engineers, providing code coaching, performance management, and career development to foster a culture of engineering excellence

Take ownership of the current TMR platform prototype, driving the architectural roadmap to evolve it into a robust, cloud-native production system capable of handling 100M+ molecules

Make high-level technical decisions regarding the stack, ensuring solutions are scalable, maintainable, and cost-effective

Establish engineering best practices (CI/CD, testing standards, code reviews) to ensure high reliability as the platform scales to support global research

Collaborate closely with Genentech Computational Sciences (gCS) and Antibody Engineering teams to translate complex scientific requirements into clear engineering deliverables

Manage project timelines and priorities, ensuring the team delivers high-impact features that unblock drug discovery programs

Qualification

Software engineeringCloud-native systemsPythonTeam managementRelational databasesScalable data systemsEngineering best practicesOpen source cheminformaticsChemical database expertiseBiological sequence alignmentCommunication skillsProject managementCollaboration

Required

12+ years of software engineering experience, with at least 3+ years specifically managing engineering teams (direct people management, not just technical lead)

Experience taking systems from prototype to production, specifically in complex data environments

Expertise in scalable data systems (handling 100B+ rows)

Strong technical proficiency in Python and relational databases (Postgres preferred)

Excellent communication skills, with the ability to bridge the gap between technical engineering constraints and scientific business goals

Preferred

Open source cheminformatics experience (e.g., RDKit, chemfp, Indigo, HELM toolkit)

Chemical database cartridge expertise

Familiarity with biological sequence alignment or chemical structure canonicalization

Benefits

Relocation benefits are available for this job posting.

A discretionary annual bonus may be available based on individual and Company performance.

Company

Genentech

Glassdoor4.1

Genentech is a biotechnology research company that specializes in genetic testing and personalized medicines.

Founded in 1976

South San Francisco, California, USA

10001+ employees

http://gene.com

H1B Sponsorship

Genentech has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (167)

2024 (148)

2023 (150)

2022 (178)

2021 (121)

2020 (158)

Funding

Current Stage

Public Company

Total Funding

unknown

2009-03-26Acquired

1999-07-20IPO

1976-01-01Series Unknown

Leadership Team

Ashley Magargee

Chief Executive Officer

Michael Laird

Vice President

Recent News

Pharma Letter

Structure Therapeutics signs patent deal with Genentech

2026-01-07

Business Wire

Ventus Therapeutics Announces Nomination of VENT-04, a First-in-Class, Oral, Small-Molecule Caspase-4/5 Inhibitor, as a Development Candidate

2026-01-07

MarketScreener

Structure Therapeutics Inc - Gasherbrum entered agreement with Genentech and Roche - SEC filing

2026-01-06

Company data provided by crunchbase