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GenEdit · 3 weeks ago

Scientist I, Nanoparticle Formulation and Process Development

South San Francisco, CA

Full-time

Onsite

Mid Level

3+ years exp

GenEdit is an early-stage company developing a novel delivery platform for genetic medicines. The role involves supporting the development of genetic medicines through nanoparticle formulation in a lab setting, with responsibilities including executing and optimizing analytical techniques and maintaining detailed lab records.

BiotechnologyGeneticsPharmaceuticalTherapeutics

No H1B

Responsibilities

Support the development of genetic medicines utilizing GenEdit’s proprietary hydrophilic nanoparticle (HNP) platform

Work full-time in our wet labs to support nanoparticle formulation activities

Execute at a high level in the lab

Keep detailed lab records

Execute, optimize, and develop analytical techniques

Cooperate efficiently with other technicians and scientists

Qualification

Nanoparticle formulationAnalytical characterizationProcess developmentMRNA encapsulationLight scattering techniquesMolecular biology techniquesExperimental designTechnical troubleshootingCommunication skillsOrganizational skills

Required

PhD (or BS/MS with significant experience) in nanoparticle sciences and formulation

3+ years of relevant hands-on lab experience, ideally in an industry setting

Required: expertise in nanoparticle formulation and related analytical characterization: optimization of mRNA and small molecule encapsulation mixing methods (IJM, microfluidics), light scattering and zeta potential (DLS, MALS), quantitative fluorescence assays (RiboGreen, fluorescamine)

Capable of independent experimental design, execution, and technical trouble shooting

Ability to efficiently execute in the lab, develop standard operating procedures with precise reproducibility, and maintain detailed electronic lab notebook records

Excellent communication, presentation, and organizational skills

Work authorization in the US is required

Preferred

Highly preferred: nanoparticle scale-up manufacturing and process development including purification and concentration methods (TFF, UF/DF, sterile filtration, analytical HPLC) and standard molecular and cell biology techniques including UV-Vis, gel electrophoresis, protein expression characterization (western blot, ELISA, flow cytometry, FlowJo) and transfection of mammalian tissue culture