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Thermo Fisher Scientific · 5 days ago

Engineer II, System Design

South San Francisco, CA

Full-time

Onsite

Entry, Mid Level

$83K/yr - $124K/yr

2+ years exp

Thermo Fisher Scientific is a global leader in providing solutions for health and safety. The Engineer II, System Design role focuses on developing next-generation sequencing instruments and optimizing automated workflows for clinical applications.

BioinformaticsBiotechnologyCloud Data ServicesConsultingHealth CareLife ScienceManagement Information SystemsOffice SuppliesPrecision Medicine

No H1B

Responsibilities

Evaluate proposed NGS systems and workflows, integrate and characterize new technologies, and establish feasibility through rigorous experimentation

Translate complex molecular biology and chemical protocols from benchtop to automated platforms

Optimize hardware-workflow interactions for performance, reliability, and robustness

Design hypothesis-driven experiments to characterize system performance and identify failure modes

Apply first-principles thinking to diagnose and resolve complex issues spanning molecular biology, chemistry, hardware, consumables, and software

Partner with assay development scientists and hardware engineers, providing data-driven feedback to guide co-development of reagents, consumables, and instrument hardware

Provide expert-level technical support for on-market instruments and Field Support teams

Develop automated hardware diagnostics and new features that integrate hardware, consumables, and software into seamless automated solutions

Qualification

Fluidic/Microfluidic SystemsMolecular BiologyScripting/ProgrammingDesign of ExperimentsCommercial Product DevelopmentCommunication SkillsOrganizational Skills

Required

Bachelor's degree in engineering or science required

2+ years of experience evaluating, integrating, testing, and troubleshooting complex fluidic/microfluidic systems required (equivalent combinations of education and relevant work experience may be considered)

Deep understanding of molecular biology, biochemistry, and liquid handling principles applied to hardware integration and system performance challenges

Proficiency in scripting/programming (Python, MATLAB, or similar) and instrument control software

Strong communication skills; ability to convey complex technical concepts to multidisciplinary teams

Proven ability to take ownership, overcome obstacles, and deliver results

Preferred

Hands-on experience translating biological/chemical workflows (library prep, templating, sequencing) onto NGS instruments in life sciences or diagnostics R&D

Experience with Design of Experiments (DOE) and statistical tools (JMP, R)

Commercial product development experience (design, prototyping, testing, documentation)

Strong organizational skills with the ability to manage multiple projects and competing priorities