St. Jude Children's Research Hospital · 2 days ago
Associate Scientist or Scientist - Yen Lab/Therapeutic Genome Engineering (TGEn Group)
Memphis, TN
Full-time
Onsite
Mid, Senior Level
$86K/yr - $155K/yr
3+ years expSt. Jude Children's Research Hospital is seeking a highly motivated Scientist or Associate Scientist to join the Therapeutic Genome Engineering (TGEn) group led by Dr. Jonathan Yen. The role involves developing genome editing strategies for treating sickle cell disease and participating in a multidisciplinary team to advance cellular therapies.
BiotechnologyCharityHealth CareHealth DiagnosticsHospitalMedicalNon Profit
Responsibilities
Perform studies to develop genome editing strategies for human hematopoietic stem cells (HSC)
Design and execute IND-enabling experiments to characterize the pharmacology of a genome-edited human hematopoietic stem cell product to treat sickle cell disease
Characterize the efficacy, safety, and potency of the HSC cellular drug product in in vitro and xenotransplantation assays
Multicolor flow cytometry and FACS to sort hematopoietic populations of relevance
Develop experimental methods including RT-PCR, ddPCR, next-generation sequencing, and single-cell sequencing
Perform NGS library preparation and analysis of editing outcomes, on-target and off-target
Evaluate scale-up and close-system processes to ensure reproducibility of the drug product
Conduct exploratory research on developing novel in-vitro and in-vivo delivery strategies
Interact and collaborate with multidisciplinary teams to advance the program
Establish tracking and trending analyses of process development and pilot runs
Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility
Maintains regular and predictable attendance
Performs other related duties as assigned to meet the goals of the department and institution
Qualification
Required
Bachelor's degree in a relevant scientific area is required
7 + years of research experience is required
5 + years of research experience is required with a Master's degree
2 + years of research experience is required with a PHD
Eight (8) years of relevant post-degree work experience is required with a Bachelor's degree
Six (6) years of relevant post-degree work experience is required with a Master's degree
Three (3) years of relevant post-degree work experience is required with a PhD
Preferred
Master's or PhD degree in a relevant scientific area is highly preferred
Experience leading and supporting research experiments preferred
Some experience leading lab and scientific project coordination, maintenance, and other research support activities preferred
Experience in guiding and training other laboratory personnel preferred
Proven performance in earlier role/comparable role
Company
St. Jude Children's Research Hospital
St.
5001-10000 employees
H1B Sponsorship
St. Jude Children's Research Hospital has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (370)
2024 (316)
2023 (309)
2022 (255)
2021 (251)
2020 (201)
Funding
Current Stage
Late StageTotal Funding
$62.4MKey Investors
Kia MotorsKBR Charity Golf TournamentHyundai Hope On Wheels
2025-05-12Grant· $1.5M
2024-10-28Grant
2024-08-28Grant· $0.4M
Leadership Team
Judy A. Habib
Chair, Board of Directors
Recent News
Genetic Engineering News
2026-01-06
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2026-01-05
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