Amgen · 2 weeks ago
Senior Principal Scientist – Target Discovery & Biology (TD&B)
Thousand Oaks, CA
Full-time
Onsite
Senior Level, Lead/Staff
6+ years expAmgen is a leading biotechnology company dedicated to serving patients living with serious illnesses. The Senior Principal Scientist in Target Discovery & Biology will lead a team focused on developing advanced in vitro models to support target discovery and functional genomics efforts across various therapeutic areas.
BiotechnologyHealth CareManufacturingPharmaceutical
Responsibilities
Provide scientific and operational leadership for a team of scientists delivering advanced in vitro models and screening-ready systems in collaboration with therapeutic area partners
Guide the design, optimization, and screen implementation of cellular models that capture disease-relevant biology, integrating insights from disease tissue profiling data
Champion partnerships with automation colleagues accelerate model deployment and reproducibility
Collaborate with Amgen therapeutic area scientists to define requirements, ensure biological relevance, and deliver systems that enable mechanistic and translational insights
Identify and implement emerging technologies in cell engineering, automation, and complex model systems to enhance the sophistication and throughput of discovery platforms
Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline
Qualification
Required
Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of directly related experience
Master's degree and 6 years of directly related experience
Bachelor's degree and 8 years of directly related experience
Preferred
Doctorate degree in cell biology, molecular biology, biomedical engineering, or related discipline
6+ years of relevant experience in biotech or pharma, including leadership of scientific teams
Strong track record in complex in vitro model development, cell engineering, and high-throughput or automated screening
Experience with high-content imaging and transcriptional assay readouts
Demonstrated ability to collaborate with cross-functional teams to translate disease biology into experimental models
Experience with viral vector systems (AAV, lentivirus, or related technologies) for gene delivery and perturbation
Experience in leading or mentoring scientists, with proven success in project execution and team development
Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights
Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment
Benefits
A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible
Company
Amgen
Amgen is a biotechnology company that develops and manufactures human therapeutics for various illnesses and diseases.
10001+ employees
H1B Sponsorship
Amgen has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (429)
2024 (485)
2023 (485)
2022 (540)
2021 (460)
2020 (444)
Funding
Current Stage
Public CompanyTotal Funding
$28.5B2022-12-12Post Ipo Debt· $28.5B
1983-06-17IPO
Leadership Team
Robert Bradway
Chairman and Chief Executive Officer
Jay Bradner
Executive Vice President of R&D, and Chief Scientific Officer
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