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Invivyd · 1 week ago

Scientist-Sr. Scientist, Structural Evolutionary Biologist

United States

Full-time

Remote

Mid, Senior Level

2+ years exp

Invivyd is a company dedicated to delivering protection from serious viral infectious diseases, particularly for immunocompromised populations. They are seeking a Structural Evolutionary Biologist to join their Research and Development Team, responsible for building computational tools and analyzing viral sequencing data to inform therapeutic monoclonal antibody development.

BiotechnologyPharmaceuticalTherapeutics

Responsibilities

Lead an effort that coordinates inputs from microbiologists, evolutionary biologists and antibody engineers to guide programming efforts to develop bioinformatic tools for use in antibody discovery and development

Analyze large sequence datasets to identify evolutionary trends, structural constraints, variant hotspots, and functional motifs in multiple viral target proteins

Develop, maintain, and optimize computational pipelines for sequence processing, structural prediction, phylogenetic analysis, and evolutionary modeling

Curate wastewater and clinical sequence database connectivity pipelines

Support protein engineering and antibody programs by providing structural and evolutionary risk assessments and actionable insights

Generate figures and animations that effectively communicate observed trends in virus evolution and target structural dynamics

Author non-clinical study reports related to pathogen surveillance in support of regulatory filings

Serve as primary point of contact for collaborations and contracts with external partners

Manage a team of programmers and developers

Collaborate closely with cross-functional teams, including other research and development groups, preclinical, clinical and regulatory teams

Qualification

Molecular evolutionComputational analysisBioinformatics toolsPython programmingJavaScript programmingSequence analysisPhylogeneticsData managementProblem-solvingCommunication skillsTeam collaborationAttention to detail

Required

PhD in a relevant scientific discipline (e.g., Computational Biology, Evolutionary Biology, Molecular Biology, Structural Biology, Biochemistry, Immunology, Microbiology)

Demonstrated expertise in microbial molecular evolution, sequence analysis, and phylogenetics

Experience working with large biological data sets and establishing quality assessment workflows for regularly updated databases

Programming skills in Python and JavaScript

Proficiency in design and maintenance of customized computational biology tools and cloud-based bioinformatics suites

Experience in managing CROs and external collaborations, including budgeting and timeline management

Strong problem-solving skills and the ability to adapt to evolving project needs

Excellent verbal and written communication skills

Ability to work independently as well as part of a multidisciplinary team

Highly organized with strong attention to detail

Inclusion of a coding portfolio as part of the application (a link to GitHub repository is preferred)

Preferred

At least 2 years of experience in the pharmaceutical or biotechnology industry, with a focus on antibody drug discovery and development or infectious diseases

Experience with SARS-CoV-2 research or similar virology-related projects

Experience in regulatory interactions and patenting strategies