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AstraZeneca · 1 day ago

Associate Principal Bioinformatics Specialist, Omics, Oncology Data Science Platforms

Waltham, MA

Full-time

Onsite

Senior Level, Lead/Staff

$136K/yr - $204K/yr

5+ years exp

AstraZeneca is a company dedicated to transforming scientific ideas into life-changing medicines. They are seeking an AI-native Bioinformatician to support oncology initiatives by designing and applying innovative computational and AI analysis methods for high-throughput molecular data generation.

BiopharmaBiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Join our growing ODSP team to support AstraZeneca Oncology's strategic initiatives in high-throughput molecular data generation, including somatic DNA sequencing, single-cell and bulk transcriptomics, proteogenomics, and digital pathology

As an AI-native Bioinformatician with expertise in NGS 'omics data, you'll design and apply innovative computational & AI analysis methods to advance our multi-omics research portfolio

Your strong quantitative skills will help build scalable solutions to interrogate diverse cancer 'omics datasets, empowering researchers to use AI systems for data-driven decision-making and biomedical knowledge generation

Qualification

Bioinformatics pipelinesAI analysis methodsNGS data analysisProgramming (Python)Cloud computing (AWS)Unix/Linux environmentsMachine learningTransformers/neural networksCommunication skillsAttention to detailTeam collaboration

Required

Master's degree in Bioinformatics, Computational Biology, or a related field with 5+ years of applied experience in bioinformatics data analysis or Ph.D. in Bioinformatics, Computational Biology, or a related field with 2+ years of experience

Deep understanding of at least one type of molecular profiling data (e.g. RNA or DNA sequencing) and experience in analysing human Illumina NGS results from raw data to insights

Direct experience with domain-specific foundation models for omics or imaging (e.g., finetuning, modality adaptation), with strong understanding of transformers/neural networks

Extensively uses AI tools for productivity like LLMs, coding copilots (e.g. Github copilot with VS Code) and research assistants

Familiarity with Agentic frameworks (e.g. LangChain, Pydantic AI) and their application to scientific problems

Experience with other machine learning, graph modelling, Bayesian analytics or other non-traditional approaches to model biological data for biomarker discovery

Proven programming skills, (Python preferred) and familiarity with software development best-practices (end-to-end tests, unit testing, version control with git)

Experience working in Unix/Linux environments, exposure to at least one common workflow language such as Nextflow or Snakemake, familiarity with package management (e.g. Conda)

Cloud computing (preferably AWS), and High-Performance Computing (HPC)

‘Builder' mindset, strategic thinker, and experience leading projects

Strong, professional communication skills and excellent attention to detail, capable of developing good effective collaborative relationships with diverse teams of technical and non-technical analysts, engineers, scientists, strategists

Experience working within a team environment

Preferred

Proficiency analysing and interpreting data from multiple 'omics platforms (NGS sequencing, transcriptomics, epigenomics, genomics, proteomics etc.) in an oncology context

Exposure to public cancer knowledgebases and resources (e.g. dbSNP, COSMIC, gnomAD, GDC, TCGA, 1000 Genomes etc)

Experience working with patient data from clinical trials and biomarker development

Well networked within external bioinformatics, NGS, and AI/ML communities

Benefits

Short-term incentive bonus opportunity

Equity-based long-term incentive program (salaried roles)

Retirement contribution (hourly roles)

Qualified retirement program [401(k) plan]

Paid vacation and holidays

Paid leaves

Health benefits including medical, prescription drug, dental, and vision coverage

Company

AstraZeneca

Glassdoor4.1

AstraZeneca is a pharmaceutical company that discovers, develops, manufactures, and markets prescription medicines. It is a sub-organization of Investor.

Founded in 1999

Cambridge, Cambridgeshire, GBR

10001+ employees

https://www.astrazeneca.com

H1B Sponsorship

AstraZeneca has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2021 (2)

2020 (11)