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Calico Life Sciences · 23 hours ago

Principal Associate Scientist (In Vitro/Ex Vivo Assay Specialist)

South San Francisco, CA

Full-time

Onsite

Senior Level, Lead/Staff

$147K/yr - $159K/yr

10+ years exp

Calico Life Sciences is an Alphabet-founded research and development company focused on understanding human aging. They are seeking a skilled In Vitro/Ex Vivo Assay Specialist to provide analytical support for preclinical pharmacology studies, develop and execute assays, and collaborate with project teams to inform key decisions based on data analysis.

Biotechnology

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Serve as the primary specialist for all in vitro and ex vivo assay needs generated from ongoing in vivo pharmacology studies

Develop, optimize, and rigorously validate novel and established assays (e.g., ELISA, western blot, qPCR, enzymatic assays, cellular functional assays) to measure pharmacodynamic (PD) markers, target engagement, and efficacy endpoints in complex biological matrices (tissue homogenates, plasma, CSF, etc.)

Process and meticulously analyze study samples generated from internal experiments and those received from external partners and Contract Research Organizations (CROs), ensuring high-quality, reproducible data

Act as a subject matter expert, training team members on assay protocols and troubleshooting complex technical issues in the lab

Perform detailed data analysis, visualization, and interpretation, which includes ensuring data integrity, performing statistical analysis, and generating clear summaries

Collaborate closely with the in vivo pharmacologists, DMPK lead and project teams to use the generated data to inform key project decisions, such as dose selection, mechanism-of-action confirmation, and candidate progression

Maintain meticulous laboratory records, standard operating procedures (SOPs), and detailed reports suitable for internal reviews and regulatory filings

Qualification

Assay DevelopmentData AnalysisBiochemical TechniquesStatistical SoftwareSample ProcessingCommunication SkillsOrganizational Skills

Required

M.S. in Cell or Molecular Biology, Biochemistry or a related discipline with 10+ years of relevant industry experience

Extensive hands-on experience with a wide range of analytical and biochemical techniques, specifically including: ELISA/MSD, Western Blotting and other protein quantification methods, qPCR/RT-PCR, Processing of complex biological samples (e.g., tissue dissection, homogenization, cell culture)

Direct experience in providing assay support for study samples generated by external partners or CROs is highly valued

Must be proficient in managing and standardizing analytical pipelines for externally sourced samples

Proficient in statistical software and data analysis tools (e.g., GraphPad Prism, Excel) for analyzing and presenting complex data sets

Strong organizational skills and excellent verbal and written communication ability to work effectively across interdisciplinary teams and manage external data streams

Must be willing to work onsite 5 days a week

Benefits

Eligible for two annual cash bonuses

Company

Calico Life Sciences

Glassdoor4.1

Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.

Founded in 2013

South San Francisco, California, USA

201-500 employees

http://www.calicolabs.com/

H1B Sponsorship

Calico Life Sciences has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

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Trends of Total Sponsorships

2025 (12)

2024 (12)

2023 (7)

2022 (10)

2021 (5)

2020 (14)