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Apogee Therapeutics · 4 weeks ago

Director, Data Engineering & Analytics

United States

Full-time

Remote

Director/Executive

$220K/yr - $235K/yr

10+ years exp

Apogee Therapeutics, Inc. is a biotechnology company focused on developing differentiated biologics for treating various inflammatory and immunology conditions. They are seeking a Director of Data Engineering & Analytics to lead the design and implementation of a new enterprise Data Lakehouse and analytics ecosystem, primarily supporting Clinical Development and Clinical Operations use cases.

BiotechnologyLife ScienceMedicalTherapeutics

H1B Sponsor Likely

Responsibilities

Serve as the primary owner of Apogee’s Data Lakehouse architecture, roadmap, and implementation, in close partnership with a Systems Integrator

Define the data platform to support Clinical Development and Clinical Operations, with a clear path to extend to Technical Operations, Commercial, Medical Affairs, and Finance

Design and oversee data ingestion, transformation, and storage for structured and semi-structured data from key Apogee sources, including external CRO systems (e.g., EDC, CTMS, safety, statistical outputs)

Establish and maintain subject area data models and semantic layers tailored to clinical and operational use cases

Ensure the platform is designed and operated in alignment with Apogee’s GxP, 21 CFR Part 11, SOX Controls, and other regulatory/compliance expectations, where applicable

Design, build, and maintain end-to-end data pipelines (ingestion, transformation, curation) into the Data Lakehouse using modern data engineering practices

Develop and maintain data models that serve Clinical Development, Clinical Operations, and later Tech Ops and Commercial / Med Affairs / Finance

Implement data quality, lineage, and metadata practices, working with business data owners to define critical data elements and trusted metrics

Contribute to defining data governance at Apogee, including data ownership, stewardship, and standardized KPI and metric definitions across functions

Design and build dashboards / analytic views that support key functional area use cases

Define reusable data marts and semantic models that enable self-service analytics for Clinical and, over time, other functions

Act as a trusted partner to Clinical Development, Clinical Operations, Biometrics, Medical Monitoring, and other functions, translating their questions into implementable data and analytics solutions

Work closely within IT (Infrastructure and Security), QA, and business stakeholders to support any required validation, testing, and controlled releases of data and analytics capabilities

Communicate roadmaps, status, risks, and dependencies clearly and regularly to technical and non-technical stakeholders, including senior leadership

Drive adoption and literacy around the Data Lakehouse and BI tools by developing documentation, providing training/enablement for key users, and promoting best practices

Help define the future operating model for data and analytics at Apogee, including when and how to scale into a broader team

Qualification

Data LakehouseData EngineeringCloud Data PlatformsData ModelingSQLETL/ELTData GovernanceData VisualizationPythonCommunication SkillsLeadership SkillsCollaboration Skills

Required

10+ years of experience in data engineering, data platform, or analytics roles, with meaningful experience owning or leading a modern cloud data platform (Data Lakehouse or cloud data warehouse)

Bachelor's degree (or equivalent professional experience) in Life Sciences, Information Systems, Engineering, or related field

Proven track record as a hands-on senior level individual contributor, comfortable both setting strategy and implementing technical solutions

Experience with cloud-based data platforms (e.g., Databricks, Snowflake, BigQuery, or similar) and modern data stack components

Strong expertise in data modeling and ETL/ELT for analytics and reporting, including building reusable, production-grade data assets

Experience working closely with integration teams (ideally with MuleSoft or similar) and understanding how operational integrations and data pipelines intersect

Strong proficiency in SQL and at least one data engineering language (e.g., Python or Scala)

Hands-on experience with data pipeline and orchestration tools (e.g., Airflow, Azure Data Factory, dbt, or similar) and CI/CD concepts for data workloads

Solid understanding of data architecture patterns (data lakes, lakehouses, warehouses, dimensional modeling, semantic layers)

Strong understanding of data security, privacy, and access control in an enterprise setting, and how these intersect with GxP and other compliance requirements

Excellent communication and storytelling skills, capable of framing data and platform decisions in business terms for clinical and executive stakeholders

Demonstrated ability to lead through influence, collaborating effectively with integration, infrastructure, security, QA, and business teams without direct reporting lines

High ownership and bias for action, comfortable operating in a fast-paced, high-growth clinical-stage biotech environment

Ability and willingness to travel up to 20%, including mandatory in-person attendance at Apogee All Hands meetings typically held twice per year

Preferred

Prior experience in biotech / pharma / life sciences is strongly preferred, especially supporting Clinical Development, Clinical Operations, Biometrics, or Medical Monitoring

Familiarity with data from CROs and clinical systems (e.g., EDC, CTMS, safety, lab, statistical outputs) and integrating these into a centralized data environment

Experience working in regulated environments (e.g., GxP, 21 CFR Part 11, HIPAA) and supporting audit/inspection readiness is highly desirable

Exposure to Apogee-relevant systems is a plus (e.g., Veeva Vault applications, Egnyte GxP repositories, SAS server, NetSuite)

Interest in eventually building and leading a small data team, while being fully comfortable as a hands-on individual contributor in the near term

Benefits

Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits

We provide competitive time off, including three weeks PTO, two one-week company-wide shutdowns a year and dedicated paid sick leave

Commitment to growing you professionally and providing access to resources to further your development

Apogee offers regular all team, in-person meetings to build relationships and problem solve

Company

Apogee Therapeutics

Apogee Therapeutics is a biotechnology company that offers therapies for immunological and inflammatory disorders.

Founded in 2022

San Francisco, California, USA

201-500 employees

https://apogeetherapeutics.com/

H1B Sponsorship

Apogee Therapeutics has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (2)

2024 (3)