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Calico Life Sciences · 5 hours ago

Principal Scientist, In Vivo Pharmacology

South San Francisco, CA

Full-time

Onsite

Lead/Staff

$198K/yr - $207K/yr

8+ years exp

Calico is an Alphabet-founded research and development company focused on understanding human aging and developing interventions for longer, healthier lives. The Principal In Vivo Pharmacologist will lead the preclinical pharmacology strategy for drug discovery programs, particularly in neurodegenerative and oncology-related diseases, while managing external partnerships and ensuring the quality of research outcomes.

Biotechnology

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Drive Preclinical Strategy: Act as a key scientific leader, defining and executing the preclinical in vivo pharmacology strategy for multiple drug discovery programs

Neurodegeneration and/or Tumor Biology Expertise: Apply specialized and deep expertise in the disease pathology and pathogenesis to guide project direction

Model Development & Validation: Lead the development, characterization, and selection of relevant in vivo models for target validation, compound screening, and mechanism-of-action studies, including establishing rigorous endpoints and ensuring model fidelity

Study Design & Execution: Design sophisticated pharmacology and efficacy studies, overseeing their execution, and ensuring they are conducted to the highest scientific and ethical standards

Data Analysis & Interpretation: Perform meticulous data analysis, interpret key findings, and translate complex results into actionable insights that inform crucial project go/no-go decisions

Primary Project Contact: Serve as the primary scientific contact for assigned project teams, ensuring seamless communication and alignment of in vivo efforts with overall program goals

CRO and External Partner Management: Strategically manage relationships with Contract Research Organizations (CROs) and external academic or industry partners, which includes: Identifying and vetting appropriate partners, Driving strategy, managing contracts, and overseeing study execution by external groups, Ensuring the quality and timely delivery of external data

Key Decision Maker: Proactively communicate findings to leadership and project teams to inform and drive key project decisions (e.g., candidate selection, IND-enabling strategy)

Qualification

Vivo PharmacologyNeurodegeneration ExpertiseOncology ExpertisePharmacodynamics ModelsCRO ManagementData AnalysisProject ManagementCommunication Skills

Required

Ph.D. in Pharmacology, Neuroscience, Tumor Biology, or a related field, with 8+ years of postdoctoral experience, including 4-6 years in the biopharma industry

Proven track record of success in preclinical in vivo pharmacology, with a focus on neurodegenerative and/or oncology diseases

Expert-level understanding of neurodegenerative and/or oncology disease pathogenesis, animal model development, and standard pharmacological study designs (PK/PD, efficacy)

Extensive experience selecting, managing, and collaborating with CROs and/or academic partners to execute in vivo studies

Exceptional written and verbal communication skills are essential

Must be able to clearly articulate complex scientific concepts, present data to diverse audiences, and write high-quality technical reports and regulatory documents

Must be willing to work onsite 5 days a week

Benefits

Two annual cash bonuses

Company

Calico Life Sciences

Glassdoor4.1

Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.

Founded in 2013

South San Francisco, California, USA

201-500 employees

http://www.calicolabs.com/

H1B Sponsorship

Calico Life Sciences has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (12)

2024 (12)

2023 (7)

2022 (10)

2021 (5)

2020 (14)