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Calico Life Sciences · 18 hours ago

Principal Scientist, Process Chemistry

South San Francisco, CA

Full-time

Onsite

Lead/Staff

$198K/yr - $241K/yr

8+ years exp

Calico is a research and development company founded by Alphabet, focused on understanding human aging and developing interventions for healthier lives. The Principal Scientist, Process Chemistry will design and optimize synthetic processes for manufacturing small-molecule intermediates and APIs, leveraging extensive experience in organic chemistry and laboratory experimentation.

Biotechnology

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates

Perform laboratory experiments to improve yields, selectivity, throughput, and impurity control

Conduct detailed reaction analysis using, HPLC, GC, LC-MS, and other analytical techniques

Perform impurity identification and synthesis

Identify and mitigate process risks related to safety, scalability, and robustness

Collaborate with cross-functional partners including analytical chemistry, formulations, and quality assurance

Prepare clear, data-driven reports and present experimental results to project teams

Support technology transfer to contract manufacturing organizations, including review of master batch records and process descriptions

Maintain accurate lab documentation and adhere to all safety and compliance standards

Qualification

Synthetic organic chemistryProcess chemistryAnalytical techniquesCGMP guidelinesProject managementProblem-solvingCommunication skillsTeam collaborationAttention to detail

Required

PhD in Organic Chemistry or related field with 8+ years of relevant industrial experience in process chemistry

Strong expertise in synthetic organic chemistry and reaction mechanism fundamentals

Demonstrated success in developing scalable synthetic processes

Proficiency with standard analytical instruments and data interpretation

Excellent problem-solving, organization, and communication skills

Ability to work independently while contributing effectively to a team environment

Familiarity with cGMP and ICH guidelines

Strong attention to detail and a commitment to high-quality experimentation

Ability to manage multiple projects and shifting priorities

A proactive, collaborative mindset with enthusiasm for process improvement

Must be willing to work onsite 5 days a week

Benefits

Two annual cash bonuses

Company

Calico Life Sciences

Glassdoor4.1

Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.

Founded in 2013

South San Francisco, California, USA

201-500 employees

http://www.calicolabs.com/

H1B Sponsorship

Calico Life Sciences has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (11)

2024 (12)

2023 (7)

2022 (10)

2021 (5)

2020 (14)