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Arrowhead Pharmaceuticals · 1 day ago

Senior Scientist I, DMPK

Madison, WI

Full-time

Onsite

Mid, Senior Level

$100K/yr - $120K/yr

3+ years exp

Arrowhead Pharmaceuticals is a clinical stage biopharmaceutical company focused on developing innovative drugs for diseases with a genetic basis. They are seeking a Senior Scientist, DMPK to lead the design and execution of preclinical DMPK studies and ensure high-quality datasets that meet regulatory expectations.

BiotechnologyHealth CareNanotechnologyPharmaceutical

Comp. & Benefits

No H1B

Responsibilities

Develop and implement in vitro and in vivo DMPK strategies to support preclinical development for compounds across multiple indications and routes of administration

Manage all DMPK activities, including oversight of internal resources and CRO partners to ensure high-quality and timely data delivery

Design, supervise, and execute preclinical PK studies, including non-compartmental analysis (NCA), data interpretation, reporting, and communication of PK/PD insights to project teams

Prepare and deliver IND-enabling DMPK packages, ensuring compliance with regulatory expectations and contributing to regulatory submissions

Apply working knowledge of GLP/GCP principles and ensure appropriate documentation for regulated studies

Support GLP toxicokinetic (TK) study design, analysis, and reporting

Oversee metabolite identification in preclinical and clinical samples using high-resolution mass spectrometry (HRMS)

Contribute to a dynamic, fast-paced DMPK team by offering scientific leadership, troubleshooting support, and cross-functional collaboration

Maintain a current understanding of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics

Qualification

DMPK expertisePhD in relevant fieldVitro ADME assaysLC–MS/MSHRMSDrug development experienceDrug biotransformationInterpersonal skillsCommunication skillsProblem-solving skills