Principal Machine Learning Engineer jobs in United States
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Microsoft · 1 day ago

Principal Machine Learning Engineer

Microsoft is a global leader in technology and innovation, and they are seeking a Principal Machine Learning Engineer to advance state-of-the-art model capabilities in health and life sciences. This role focuses on leading the design and development of machine learning models and collaborating with interdisciplinary teams to ensure the effectiveness and compliance of ML workflows.

Agentic AIApplication Performance ManagementArtificial Intelligence (AI)Business DevelopmentDevOpsInformation ServicesInformation TechnologyManagement Information SystemsNetwork SecuritySoftware
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Growth Opportunities
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H1B Sponsor Likelynote

Responsibilities

Lead the design and development of machine learning models and systems for health and life sciences applications, ensuring scalability and reliability
Define technical strategy and architecture for ML pipelines, including data ingestion, feature engineering, model training, evaluation, and deployment
Collaborate with interdisciplinary teams (including scientists, researchers, and software engineers) to envision and develop AI-augmented scientific systems
Mentor engineers and researchers, promoting best practices in ML development, experimentation, and responsible AI principles
Ensure security, privacy, and regulatory compliance across ML workflows and data handling

Qualification

Machine LearningML algorithmsModel optimizationPyTorchTensorFlowDistributed trainingData ingestionFeature engineeringModel deploymentSecurity complianceCollaborationProblem solving

Required

Bachelor's Degree in Computer Science or related technical field AND 6+ years technical engineering experience with coding in languages including, but not limited to, C++, C#, Java, JavaScript, or Python + OR equivalent experience

Preferred

Masters in Computer Science or related technical field AND 6+ years technical engineering experience including significant work in machine learning or applied AI + OR equivalent experience
Proven track record of designing and deploying large-scale ML or MLops systems in research or product settings
Hands-on experience with large-scale distributed training of ML models
Deep expertise in ML algorithms, model optimization, and frameworks (e.g., PyTorch, TensorFlow)
Experience with one or more of: optimizing data mixes, mid-training, post-training, model merging, or model distillation
Familiarity with security and compliance standards for enterprise and health data
Demonstrated ability to communicate effectively and solve problems in collaborative, research-driven environment

Company

Microsoft

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Microsoft is a software corporation that develops, manufactures, licenses, supports, and sells a range of software products and services.

H1B Sponsorship

Microsoft has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (9192)
2024 (9343)
2023 (7677)
2022 (11403)
2021 (7210)
2020 (7852)

Funding

Current Stage
Public Company
Total Funding
$1M
Key Investors
Technology Venture Investors
2022-12-09Post Ipo Equity
1986-03-13IPO
1981-09-01Series Unknown· $1M

Leadership Team

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Satya Nadella
Chairman and CEO
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Vukani Mngxati
Chief Executive Officer - Microsft South Africa
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Company data provided by crunchbase