Denali Therapeutics · 1 day ago
Scientist, Oligonucleotide Analytical Development
South San Francisco, CA
Full-time
Onsite
Senior Level
$125K/yr - $158K/yr
5+ years expDenali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases. This position will carry out oligonucleotide analytical development to support the Oligonucleotide Transport Vehicle (OTV) platform, contributing to several programs as they enter the clinical phase.
BiotechnologyGeneticsHealth DiagnosticsTherapeutics
Responsibilities
Design, execute, and interpret stability-indicating chromatographic methods for ASOs/siRNA
Develop and apply complementary characterization techniques for ASOs/siRNA, including UV–Vis spectroscopy, mass spectrometry, NMR, Karl Fischer titration, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and circular dichroism (CD)
Analyze and interpret results, leveraging knowledge of oligonucleotide synthesis and purification processes to understand impurity profiles
Transfer analytical methods and manage activities at partner CDMOs, as needed (travel may be required)
Author and/or review analytical data, specifications, Certificates of Analysis, and method validation protocols and reports
Collaborate with discovery scientists, process chemists, quality, and project teams to advance our portfolio and analytical strategies and ensure timely flow of information
Experience with modern artificial intelligence or machine-learning approaches to support chemistry workflows is a plus
Perform other responsibilities as needed
Qualification
Required
M.Sc./B.Sc. with 5+ years of relevant experience, with a record of scientific leadership and innovation as demonstrated by publications and/or patents
Deep understanding of and demonstrated excellence in the analysis of oligonucleotides and their starting materials
Expertise in mass spectrometry is expected
Knowledge of phase-appropriate QC/analytics relevant to oligonucleotide analysis
Strong written and verbal communication skills
Preferred
Experience with modern artificial intelligence or machine-learning approaches to support chemistry workflows is a plus
Benefits
401k
Healthcare coverage
ESPP
A broad range of other benefits
Company
Denali Therapeutics
Denali Therapeutics is dedicated to defeating neurodegenerative diseases to deliver safe and effective medicines to patients and families.
501-1000 employees
H1B Sponsorship
Denali Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (11)
2024 (14)
2023 (7)
2022 (6)
2021 (5)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$1.32BKey Investors
Royalty PharmaBaillie Gifford
2025-12-04Post Ipo Debt· $200M
2024-02-27Post Ipo Equity· $500M
2022-10-19Post Ipo Equity· $275M
Leadership Team
Ryan Watts
CEO
Peter Chin
Sr. Vice President & Head of Late-Stage Clinical Development and Medical Affairs
Recent News
Longevity.Technology
2026-01-03
Company data provided by crunchbase