St. Jude Children's Research Hospital · 1 day ago
Bioinformatics Research Scientist (Immunology & TCR Repertoire) - Jeremy Chase Crawford Lab
Memphis, TN
Full-time
Onsite
Senior Level
$86K/yr - $155K/yr
6+ years expSt. Jude Children's Research Hospital is seeking a Bioinformatics Research Scientist to lead computational analysis in the Jeremy Chase Crawford Lab. This role focuses on designing and developing data analysis pipelines for next-generation immune repertoire sequencing data, specifically in the context of immunology and pediatric immune development.
BiotechnologyCharityHealth CareHealth DiagnosticsHospitalMedicalNon Profit
Responsibilities
Develop and maintain robust pipelines to automate the parsing, quality control, and characterization of human sequencing data
Create automated reporting tools to characterize clonal expansion across longitudinal samples and assess sensitivity differences between assay platforms
Perform paired chain (alpha/beta) analysis to infer patient HLA genotypes and "de-orphan" single-chain TCRs from earlier time points
Utilize network analysis approaches to infer the epitopes recognized by expanding TCR clones
Create and maintain databases to track subject and sample metadata, ensuring data integrity for any possible audits
Merge wetlab and computational data sources (LIMS, Spreadsheets, devices, bioinformatic pipelines etc.) to create up-to-date reports in PoweBI
Design and optimize a static and iteratively updated TCR/epitope matching database to predict antigen specificity
Evaluate data for quality assurance and mine relevant bioinformatics databases to support wet-lab validation
Work closely with wet-lab scientists to design experiments (e.g., defining sample exclusion criteria based on expansion evidence) and interpret complex immunological data
Assist in the evaluation of products and solutions pertaining to St. Jude's technology needs (e.g., cloud computing integration)
Qualification
Required
Bachelor's degree with 4+ years experience, Master's with 2+ years, or PhD with no work experience in Bioinformatics, Computational Biology, or a related field
Demonstrated ability to independently perform advanced statistical analysis and algorithm implementation
Experience in at least one programming language (Python preferred) and statistical package (R)
Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field
Minimum Requirement: Bachelor's degree with 6+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry)
Experience in at least one programming or scripting language and at least one statistical package, with R preferred
Preferred
Experience with immune repertoire tools (e.g., MiXCR, VDJtools, TCRdist) and handling paired-chain sequencing data
Familiarity with HLA inference algorithms and epitope prediction models
Experience interacting with High-Performance Computing clusters (LSF) and strong experience with environment management using Conda/Mamba to ensure reproducible analysis pipelines
Experience working with relational databases (MSSQL/MySql/PostgreSQL) and reporting tools (PowerBI/Tableau)
Company
St. Jude Children's Research Hospital
St.
5001-10000 employees
H1B Sponsorship
St. Jude Children's Research Hospital has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
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Trends of Total Sponsorships
2025 (370)
2024 (316)
2023 (309)
2022 (255)
2021 (251)
2020 (201)
Funding
Current Stage
Late StageTotal Funding
$62.4MKey Investors
Kia MotorsKBR Charity Golf TournamentHyundai Hope On Wheels
2025-05-12Grant· $1.5M
2024-10-28Grant
2024-08-28Grant· $0.4M
Leadership Team
Judy A. Habib
Chair, Board of Directors
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