Twist Bioscience · 2 weeks ago
Bioinformatics Engineer - Nextflow and AWS Specialist (6 months contract)
United States
Contract
Remote
Senior Level
5+ years expTwist Bioscience is a company that synthesizes genes from scratch, aiming to revolutionize genomics through their unique DNA Synthesis Platform. They are seeking a Senior Bioinformatics Engineer with expertise in Nextflow and AWS to architect and optimize bioinformatics pipelines for large-scale NGS data processing while collaborating with various teams.
B2BBiotechnologyChemicalHealth CareLife Science
Responsibilities
Architect and develop advanced Nextflow pipelines for NGS data processing, analysis, and multi-step workflow orchestration
Deploy, operate, and optimize pipelines on AWS EKS and Batch
Build and maintain Docker-based container environments for reproducible and portable bioinformatics pipelines
Develop and maintain robust Python tooling to support workflow automation, QC reporting, monitoring, and data integration
Implement workflow observability, logging, and cost-optimized execution strategies for large-scale genomic data
Collaborate with sequencing, bioinformatics, and platform engineering teams to improve workflow reliability and performance
Establish best practices for pipeline versioning, continuous integration, automated testing, and cloud-based deployment
Ensure pipelines are highly reproducible, fault-tolerant, and suitable for production environments in regulated or high-stakes settings
Qualification
Required
5+ years of experience in bioinformatics, computational biology, workflow engineering, or related fields
Expert-level proficiency in Nextflow, including DSL2, modules, workflow optimization, and pipeline debugging
Strong hands-on experience with AWS, particularly: EC2 compute environments, S3 for cloud storage, EKS for workflow execution
Deep expertise with Docker, including custom image creation, multi-stage builds, and best practices for pipeline reproducibility
Strong Python development skills with production-level experience, testing frameworks, packaging, and tooling
Experience operating in cloud-native environments with distributed computing, autoscaling, cost-optimization, and workflow orchestration
Solid understanding of NGS data formats, sequencing workflows, and common bioinformatics tools
Strong Linux skills and experience with CI/CD systems
Ability to work effectively in PST time zone (remote or onsite)
Preferred
Experience with Java/Groovy
Experience building and using APIs
Experience with Nextflow Tower or similar workflow management platforms
Experience configuring Kubernetes workloads for genomics pipelines
Background in synthetic biology, DNA design, or high-throughput genomic library analysis
Experience collaborating with wet labs or platform teams on sequencing pipeline requirements
Company
Twist Bioscience
Twist Bioscience is a biotechnology company that offers synthetic DNA solutions, gene synthesis, and variant libraries.
501-1000 employees
H1B Sponsorship
Twist Bioscience has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (18)
2024 (14)
2023 (22)
2022 (19)
2021 (4)
2020 (6)
Funding
Current Stage
Public CompanyTotal Funding
$553.11MKey Investors
Capital World InvestorsBiomatics Capital PartnersIllumina
2022-02-09Post Ipo Equity· $250M
2020-01-27Post Ipo Equity· $50M
2018-10-30IPO
Leadership Team
Emily Leproust
CEO
Siyuan Chen
Chief Technology Officer
Recent News
2026-01-07
2025-12-30
Company data provided by crunchbase