Apply on Employer Site

Flagship Pioneering · 3 weeks ago

Pioneering Medicines: Principal Scientist / Associate Director , Non-Clinical Pharmacology

Cambridge, MA USA

Full-time

Onsite

Mid, Senior Level, Lead/Staff

$148K/yr - $204K/yr

5+ years exp

Pioneering Medicines, Flagship Pioneering’s in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients. They are seeking a Principal Scientist / Associate Director to serve as the nonclinical pharmacology lead across programs in inflammation, autoimmunity, and immuno-oncology, guiding an internal in vivo team and managing external partners to generate robust data.

FinanceFinancial ServicesVenture Capital

H1B Sponsor Likely

Responsibilities

Serve as Pharmacology Lead on cross-functional program teams; define the in vivo plan, milestones, budgets, and success criteria from target validation to IND

Design and execute disease & target-relevant efficacy models and PD/biomarker readouts across inflammation, autoimmunity, and IO (contributing hands on when necessary)

Partner with DMPK/QSP to translate exposure–response into dose, route, schedule, and combination recommendations

Introduce and build new models/technologies as fit-for-purpose

Work closely with other FSP companies to develop research strategies and evaluate new programs

Qualification

Vivo pharmacologyPK/PD assessmentsVivo modelsGene-based therapyAnimal Care protocol writingMatrix environment experienceCollaborative mindsetCommunication

Required

PhD, DVM, MS or equivalent in in vivo pharmacology or related discipline with a minimum of 5 years of experience within the Pharmaceutical/Biotechnology sector required

Extensive understanding of PK/PD assessments in models of disease and experience in designing ex vivo studies to assess PD and target engagement endpoints, is a must-have

Experience managing in vivo personnel and external CRO partners in a dynamic and fast-paced research environment

Excellent communication and writing skills

Preferred

Hands on experience with in vivo models of inflammation, autoimmunity and/or immuno-oncology preferred with PD endpoints including flow/IHC/cytokine assessments

Experience working with standard modalities, such as small molecules, antibodies and peptides desired

Experience working in program teams in a matrix environment

Working knowledge of gene-based therapy approaches (gene regulation, RNA medicine, gene therapy, gene editing, and/or gene silencing) desirable but not required

Collaborative mindset and a willingness to work with different teams

Experience with Animal Care and Use protocol writing

Benefits

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Company

Flagship Pioneering

Glassdoor3.3

Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.

Founded in 2000

Cambridge, Massachusetts, USA

501-1000 employees

http://flagshippioneering.com

H1B Sponsorship

Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (8)

2024 (4)

2023 (4)

2022 (4)

2021 (1)