Eli Lilly and Company · 1 day ago
Advisor - Oligonucleotide Analytics
Indianapolis, IN
Full-time
Onsite
Mid, Senior Level
$126K/yr - $205K/yr
2+ years expEli Lilly and Company is a global healthcare leader headquartered in Indianapolis, Indiana, focused on discovering and delivering life-changing medicines. The role of Advisor - Oligonucleotide Analytics involves designing and implementing analytical methodologies for oligonucleotides, collaborating with cross-functional teams, and ensuring high standards of laboratory practice.
BiotechnologyHealth CareMedicalPharmaceutical
Responsibilities
Design, develop, optimize, and standardize robust analytical methods—including LC, LC-MS, CE-MS, and SEC/AEX-MALS—for the characterization of oligonucleotides and their conjugates across all stages of drug discovery
Proactively evaluate and implement innovative analytical technologies to overcome challenges in the analysis of complex, chemically modified oligonucleotides and ensure continued scientific advancement
Partner with cross-functional teams—including chemistry, biology, technology platform, and automation groups—to identify, develop, and implement the right instrumentation and analytical assays to accelerate chemistry design, enable structure–activity relationship understanding, and strengthen internal analytical capabilities
Utilize analytical software and collaborate with IT partners to advance laboratory informatics systems that ensure efficient data acquisition, processing, traceability, and data integrity
Continuously refine and enhance existing analytical methods and assays, and innovate as needed to meet evolving program requirements
Rapidly assimilate new technologies and apply cross-disciplinary scientific principles to solve complex analytical challenges
Maintain thorough, accurate, and timely documentation of experiments, protocols, and results in electronic laboratory notebooks and technical reports
Ensure high standards of laboratory practice, including safety and quality compliance, and promote operational excellence in all analytical activities
Communicate scientific findings, progress, and technical recommendations clearly and effectively, including regular presentations in project team, departmental, and governance forums
Qualification
Required
PhD in Analytical Chemistry, Chemistry, Bioanalysis, Pharmaceutical Sciences or other similar scientific areas with 2+ years of relevant post-graduate experience
Strong expertise in LC-MS method development
Solid understanding of oligonucleotides and their associated conjugates
Design, develop, optimize, and standardize robust analytical methods—including LC, LC-MS, CE-MS, and SEC/AEX-MALS—for the characterization of oligonucleotides and their conjugates across all stages of drug discovery
Proactively evaluate and implement innovative analytical technologies to overcome challenges in the analysis of complex, chemically modified oligonucleotides
Partner with cross-functional teams—including chemistry, biology, technology platform, and automation groups—to identify, develop, and implement the right instrumentation and analytical assays
Utilize analytical software and collaborate with IT partners to advance laboratory informatics systems
Continuously refine and enhance existing analytical methods and assays
Rapidly assimilate new technologies and apply cross-disciplinary scientific principles to solve complex analytical challenges
Maintain thorough, accurate, and timely documentation of experiments, protocols, and results in electronic laboratory notebooks and technical reports
Ensure high standards of laboratory practice, including safety and quality compliance
Communicate scientific findings, progress, and technical recommendations clearly and effectively
Preferred
Extensive experience in LC and LC-MS method development, optimization, and troubleshooting
Proficient in characterization of biologics and oligonucleotides
Strong understanding of structure–activity relationships (SAR) for therapeutic oligonucleotides and biologics
Proven track record in developing diverse analytical and separation methods, including LC, LC-MS, ion-pairing LC, SEC, CE, HILIC, HIC, and IEX
Ability to evaluate, adopt, and implement emerging analytical technologies (e.g., high-resolution MS, oligonucleotide mapping, intact mass analysis, charge-variant analysis, peptide mapping)
Hands-on experience with operation, maintenance, and troubleshooting of analytical systems including UPLC, LC-MS, CE, MALS, SPR, and CD platforms
Familiarity with Agilent, Waters, and Thermo systems and associated software (e.g., ChemStation, OpenLab CDS, BioConfirm, MassHunter, Chromeleon, BioPharma Finder, Xcalibur, Empower, MassLynx, MassMetaSite)
Experience with data processing and chromatographic software (e.g., PEAKS, Genedata-associated platforms, AutoChrom, DryLab, Fusion QbD, ChromSword)
Prior experience in proteomics, bioanalysis, and/or biophysical characterization is a strong plus
Highly self-motivated with the ability to independently lead and deliver complex projects
Excellent written and verbal communication skills, with strong cross-functional collaboration capabilities
Open-minded, detail-oriented, and committed to continuous learning in a fast-paced environment
Proven ability to manage multiple priorities, navigate ambiguity, and deliver high-quality results under tight timelines
Benefits
Company bonus
401(k)
Pension
Vacation benefits
Medical, dental, vision and prescription drug benefits
Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
Life insurance and death benefits
Certain time off and leave of absence benefits
Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)
Company
Eli Lilly and Company
We're a medicine company turning science into healing to make life better for people around the world.
10001+ employees
H1B Sponsorship
Eli Lilly and Company has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (514)
2024 (236)
2023 (167)
2022 (133)
2021 (57)
2020 (52)
Funding
Current Stage
Public CompanyTotal Funding
$6.5M2024-02-12Post Ipo Debt· $6.5M
1978-01-13IPO
Leadership Team
David Ricks
Chair, CEO
Lucas Montarce
Executive Vice President and Chief Financial Officer
Recent News
2026-01-11
2026-01-11
2026-01-11
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