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Calico Life Sciences · 3 weeks ago

Principal Scientist, Antibody Engineering & Rational Design

South San Francisco, CA

Full-time

Onsite

Lead/Staff

$198K/yr - $241K/yr

8+ years exp

Calico Labs is an Alphabet-founded research and development company focused on understanding human aging to devise interventions for healthier lives. The Principal Scientist will bridge computational design and experimental validation in antibody discovery, serving as a liaison between wet-lab and machine learning teams while leading projects and ensuring rigorous validation of computational predictions.

Responsibilities

Serve as the primary scientific liaison between our wet-lab antibody team and our machine learning team

Drive the evolution of our 'Design-Build-Test-Learn' cycle

Translate complex in silico designs into actionable experimental workflows

Ensure that computational predictions are rigorously validated and that the resulting biological data is structured to actively retrain and refine our internal models

Champion a rational, data-driven approach to biologic drug discovery

Qualification

Therapeutic antibody developmentComputational modelingStructural biologyMachine learning toolsBiophysical characterizationData-driven approachProject leadershipProblem-solving

Required

Ph.D. in molecular biology, biochemistry, computational modeling, structural biology, or related discipline

8+ years' post-PhD experience in antibody/protein engineering within the biotech or biopharma sectors

Demonstrated ability to work intimately with data scientists and ML engineers and able to articulate biological constraints (e.g., immunogenicity, manufacturability) to computational teams and interpret their in silico outputs for experimental validation

Hands-on proficiency with structural modeling and extensive knowledge in ML protein design tools

Expert knowledge of antibody structure-function relationships

Extensive experience in rational design for humanization, affinity maturation, pH-dependence, and liability removal

Deep expertise in engineering multi-specific antibodies

Strong understanding of biophysical characterization to ensure designed molecules are developable therapeutics

Experience technically managing CROs for gene synthesis, protein production, and functional assays

Ability to propose novel scientific approaches and solve complex technical hurdles independently

Must be willing to work onsite 5 days a week

Preferred

Experience designing experiments specifically to generate high-quality training data for ML models (e.g., focused libraries, systematic mutagenesis) is highly desirable

Benefits

This position is also eligible for two annual cash bonuses.

Company

Calico Life Sciences

Glassdoor4.1

Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.

Founded in 2013

South San Francisco, California, USA

201-500 employees

http://www.calicolabs.com/

H1B Sponsorship

Calico Life Sciences has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

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2025 (12)

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