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Calico Life Sciences · 1 day ago

Senior/Principal Scientist, Chemoproteomics

South San Francisco, CA

Full-time

Onsite

Senior Level, Lead/Staff

$166K/yr - $207K/yr

5+ years exp

Calico is a research and development company focused on understanding human aging and developing interventions for healthier lives. They are seeking an experienced Scientist to join the mass spectrometry proteomics group, primarily working with chemoproteomics techniques to support drug discovery efforts.

Biotechnology

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

Prepare samples from many sources, including proteins, cells, tissues and biofluids

Optimize, develop and apply proteomics and chemoproteomics sample preparation methods

Maintain and troubleshoot instruments including HPLCs, mass spectrometers and other bioanalytical equipment

Analyze data to share with collaborators

Present results at internal lab meetings and company-wide meetings

Qualification

Mass spectrometryProteomics methodsHPLC maintenanceData analysis PythonData analysis RData analysis MATLABChemoproteomicsMultiplexed proteomicsPTM analysisActivity based profilingFlexibleDetail-orientedTeamworkCommunication skillsSelf-motivated

Required

PhD in Analytical Chemistry, Chemistry, Chemical Biology, Biochemistry, Chemical Engineering or related field

Minimum 5 years technical experience post-PhD with experience in the biopharma industry

Experience in method development for HPLC and/or mass spectrometers

Experience in maintaining and troubleshooting HPLCs and mass spectrometers

Experience in sample preparation for proteomics and chemoproteomics

Experience in multiplexed proteomics (e.g. TMT)

Experience in enrichment and analysis of PTMs

Experience with activity based proteome profiling and cysteine enrichment workflows (e.g. CysPAT, DBIA)

Experience in proteomics data analysis and programming (Python, R, MATLAB)

Detail-oriented and organized

Strong teamwork and communication skills

A track record of strong research/drug discovery productivity

Self-motivated with a 'can-do' attitude is required for success

Flexible, able to respond quickly to shifting priorities and able to multitask

Must be willing to work onsite five days per week

Preferred

Experience with Thermo mass spectrometers (Lumos/Eclipse/Astral)

Experience with Agilent mass spectrometers and Rapid Fire

Experience with high throughput proteomics and automation (e.g. Hamilton Vantage)

Experience with Click chemistry

Experience with Top down proteomics

Benefits

This position is also eligible for two annual cash bonuses.

Company

Calico Life Sciences

Glassdoor4.1

Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies.

Founded in 2013

South San Francisco, California, USA

201-500 employees

http://www.calicolabs.com/

H1B Sponsorship

Calico Life Sciences has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

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Trends of Total Sponsorships

2025 (12)

2024 (12)

2023 (7)

2022 (10)

2021 (5)

2020 (14)