GSK · 1 day ago
In Vivo Respiratory Principal Scientist
Collegeville, PA
Full-time
Onsite
Senior Level, Lead/Staff
4+ years expGSK is a global biopharma company focused on uniting science, technology, and talent to advance health. The In Vivo Respiratory Principal Scientist will lead the design and execution of preclinical studies related to respiratory diseases, utilizing in vivo and ex vivo models to support drug discovery projects.
BiotechnologyHealth CarePharmaceutical
Responsibilities
Contribute to the design and lab/vivarium-based execution of in vivo strategies for the respiratory disease area
Contribute to the delivery of Respiratory preclinical efficacy and mechanistic in vivo studies using respiratory models to enable PK/PD and translational biomarker data generation
Lead discussions to ascertain a robust understanding of scientific rationale, key objectives, endpoints and Go/No-Go decisions for in vivo models and studies, setting clear goals and timelines
Use understanding of PK/PD principles relating to respiratory diseases to drive innovation and independently design, execute, analyze, and present in vivo studies as the In Vivo Leader (IVL) representative on portfolio projects with input from Biology Leader (BL), Project Leader (PL), and Complex Models Leadership Team
Understand and independently apply robust study design (RSD) principles, gain input from Subject Matter Experts and matrix partners (e.g. LASG, Statistics, PK modelling, Histopathology, Dispensary, Biopharm and Chemistry) prior to seeking endorsement/recommendations for animal studies at Independent Scientific Review (ISR) forum and Pre-Study Briefings (PSB)
Anticipate any potential challenges with experiments and independently resolve technical issues in experimental planning, setup and execution with minimal guidance
Lab/vivarium-based execution to enable sample/tissue acquisition, processing, and analysis to enable integration of PK/PD and translational biomarker data from in vivo studies and where necessary utilize advanced ex vivo assay techniques such as Flow cytometry, ELISA’s, MSD, Luminex and qPCR
Key contact for animal studies, including provision of out of hours procedures as required
Responsible for maintaining technical expertise/competency and confidence in animal handling, dosing, blood and tissue collection, and measurements of biological/physiological function (e.g. lung function, Hemodynamics)
Be familiar with Federal Laws surrounding animal use in research and the local governance process (IACUC, AUP)
Be familiar with severity limits/constraints related to adverse effects and respond as required under IACUC, AUP and GSK Policy on Care, Welfare and Treatment of Animals
Take responsibility for assessing animal health and welfare, document findings, and act on them or seek expert advice when necessary
Work effectively with internal matrix partners (e.g. BL, PL, RTech)
Lead animal studies placed externally (e.g. CRO, academic groups) including Study Monitoring responsibilities
Maintain accurate, up to date and detailed electronic laboratory records in alignment with data integrity standards and ensure compliance with all relevant written standards, SOPs, Risk Assessments and safety guidelines
Foster an enterprise culture of innovation, collaboration, inclusion, and continuous learning
Keep up to date with the relevant literature and apply to in vivo strategies and studies
Qualification
Required
BSc in a biological science and 5+ years respiratory in vivo experience or Masters in a Biological Science with 4+ years respiratory in vivo experience or PhD in a biological science and 2+ years respiratory in vivo experience either in industry or an academic environment
Current experience and knowledge of respiratory disease mechanisms involved in COPD and IPF/ILD and use of in vivo systems to interrogate pathophysiological mechanisms in these diseases
Current hands-on experience of animal model systems in the respiratory disease area including lung function measurement (e.g. Whole-Body Plethysmography, Dynamic Compliance and resistance, FEV and FVC)
Current hands-on lab/vivarium-based experience in using in vivo models in the respiratory disease area including relevant animal handling, dosing (intra-nasal and intra-tracheal), tissue necropsy (BAL and lung dissection), and blood sampling
Experience of Flow cytometry (processing of respiratory-relevant tissues), ELISA's, MSD, Luminex and qPCR or RNAseq
Experience with overseeing external animal studies conducted at CRO or academic groups as study monitor
Experience with writing and critiquing scientific documents and independently communicating scientific ideas and experimental findings, both verbally and in written form to line and matrix teams
Preferred
Expertise in biomarker assay development in the respiratory disease area to define PKPD parameters and inform translational research
Experience in drug discovery processes within the pharmaceutical or biotech industry and knowledge of the drug discovery pillars
Familiarity with omics platforms (spatial, bulk and single cell RNA seq) and advanced imaging technologies
Proven ability to balance multiple priorities and meet deadlines
Knowledge of regulatory guidelines relating to use of animals in research and compliance requirements
Benefits
Comprehensive benefits program GSK offers US employees
Company
GSK
We are uniting science, technology and talent to get ahead of disease together. Our community guidelines: https://gsk.to/socialmedia
10001+ employees
H1B Sponsorship
GSK has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (45)
2024 (56)
2023 (54)
2022 (53)
2021 (54)
2020 (72)
Funding
Current Stage
Public CompanyTotal Funding
$25.51MKey Investors
CARB-X
2021-03-02Grant· $18M
2020-09-23Grant· $7.51M
1978-01-13IPO
Leadership Team
Julie Brown
CFO
Mike Elmore
SVP & Chief Information Security Officer, GSK
Recent News
EIN Presswire
2025-11-24
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