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AstraZeneca · 2 weeks ago

Project Toxicologist, Director – Oncology Targeted Delivery (OTD) Safety Science, Clinical Pharmacology and Safety Sciences

Waltham, MA

Full-time

Hybrid

Director/Executive

$179K/yr - $268K/yr

10+ years exp

AstraZeneca is dedicated to eliminating cancer as a cause of death through innovative treatment options. The Director, Project Toxicologist will contribute to the development of novel targeted oncology medicines and will be responsible for designing regulatory toxicology studies and developing strategies to mitigate safety risks.

BiopharmaBiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine

Comp. & Benefits

H1B Sponsor Likely

Responsibilities

As core member of the project toxicology team, you will design regulatory and investigative toxicology studies to and devise a strategy to predict, assess and mitigate target- and modality-related safety risks on project teams, with a focus on Radio Conjugates, Antibody-Drug Conjugates or Small Molecules

Apply your toxicology knowledge to predict clinical safety risks and inform decision-making in drug discovery and development programs

Develop and implement innovative solutions to combine regulatory toxicology with cutting edge science and technologies to progress novel drug candidates to the clinic and through development to the market, in line with business needs

Communicate clear positions on integrated risk assessments in various formats including informing decision-making governance bodies and contribute to regulatory submissions

Maintain expertise in regulatory requirements and preclinical safety approaches applied to relevant modalities and awareness of industry trends

Provide specialist non-clinical safety expertise for evaluation of in-licensing opportunities

Develop Oncology Safety science through collaborative networks across AstraZeneca R&D, external collaborations, publications etc

Qualification

PhD in ToxicologyProject Toxicologist experienceOncology expertiseRegulatory toxicology strategiesNon-clinical toxicology studiesDrug discovery knowledgeCommunication skillsTeam-oriented approachProblem-solving skillsInterpersonal skills

Required

Excellent scientist with a PhD and/or DABT in Toxicology, Pharmacology, Oncology or related field, a strong scientific track record, and a willingness to challenge conventional thinking

Experience working as a Project Toxicologist, Investigative Toxicologist or similar safety focussed role within the pharmaceutical/biotech/CRO project environment with at least 10 years of relevant professional experience

A proven understanding of drug discovery and development and track record of delivering toxicology programs to enable progression of candidates into the clinic

Expertise in Oncology, and preferably a solid understanding of drug safety aspects of Radio Conjugates or ADCs

Experience delivering non-clinical toxicology studies in support of IND applications

Experience with the use of in vitro, in silico and in vivo approaches to predict clinical risks for oncology therapeutics; familiarity with organ-on-chip, imaging and omics for mechanistic insight

A collaborative, team-oriented approach, able to solve problems in a goal-focused fashion with capacity to coordinate tasks across multiple projects

Able to work independently and deliver toxicology risk assessments in drug development

Excellent communication, presentation, interpersonal and influencing skills across levels/subject areas with a strong desire to drive personal development

Experience and desire to work with teams across geographies including awareness of inclusion and diversity. Adopting a working style that is inclusive and collegiate, contributing to our Great Place to Work objectives

Benefits

Short-term incentive bonus opportunity

Equity-based long-term incentive program (salaried roles)

Retirement contribution (hourly roles)

Qualified retirement program [401(k) plan]

Paid vacation and holidays

Paid leaves

Health benefits including medical, prescription drug, dental, and vision coverage

Company

AstraZeneca

Glassdoor4.1

AstraZeneca is a pharmaceutical company that discovers, develops, manufactures, and markets prescription medicines. It is a sub-organization of Investor.

Founded in 1999

Cambridge, Cambridgeshire, GBR

10001+ employees

https://www.astrazeneca.com

H1B Sponsorship

AstraZeneca has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2021 (2)

2020 (11)