Bristol Myers Squibb · 1 month ago
Principal Scientist Computational Biology
Cambridge, MA
Full-time
Onsite
Senior Level, Lead/Staff
$167K/yr - $202K/yr
4+ years expBristol Myers Squibb is a biopharmaceutical company dedicated to transforming patients' lives through science. They are seeking a Principal Scientist in Computational Biology to join their Neuroscience, Immunology, and Cardiovascular discovery team, where the role involves applying analytical skills to various biological datasets and contributing to the discovery of new therapeutic targets for neurodegenerative diseases.
BiotechnologyHealth CareMedicalPharmaceuticalPrecision Medicine
Responsibilities
Perform computational research on high-dimensional readouts from perturbation experiments/screens (e.g. CRISPR screens, perturb-seq, cellular imaging)
Apply machine learning, and other advanced computational approaches, to compare high-dimensional experimental readouts to disease states defined by patient data (including transcriptomics, proteomics, single cell omics, and imaging)
Work as part of a cross-functional team that will nominate and validate new targets for neurodegeneration and neuropsychiatry
Work with external partners in industry, academia, and pre-competitive collaborations (e.g. NIH Accelerating Medicines Partnership) on novel computational and experimental approaches
Communicate findings and recommend follow-up actions in multiple settings (including 1 1, seminars, and team meetings)
Qualification
Required
Bachelor's Degree 8+ years of academic / industry experience
Or Master's Degree 6+ years of academic / industry experience
Or PhD 4+ years of academic / industry experience
Preferred
PhD from a recognized institution in a quantitative field such as computational biology, computational genomics/genetics, computer science, statistics, mathematics, or other related discipline and 5+ years of post-graduate experience
Advanced hands-on knowledge of at least one high-level programming language such as R or Python for computational research and reproducible research practices
5+ years of post-graduate experience in computational biology research (biopharma industry preferred) with track record (such as scientific publications) in driving and advancing research projects/programs with computational approaches
Hands on experience analyzing and integrating high-dimensional molecular datasets such as multi-omics (RNA-seq, ATAC-seq, proteomics, ChIP-seq/CUT&RUN), single cell (CITE-seq, scATAC-seq, perturb-seq) and spatial profiling (Visium, GeoMx, CosMX)
Experience implementing and/or developing statistical methodologies and machine learning algorithms applied to the biological problems
Background in Neuroscience, especially in neuro-degenerative diseases strongly preferred
Experience applying computer vision models to cellular imaging data preferred
Scientific curiosity with an ability of self-learning
Strong oral and written communication skills
Benefits
Health Coverage Medical, pharmacy, dental, and vision care.
Wellbeing Support Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Paid Time Off
US Exempt Employees flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
Company
Bristol Myers Squibb
At Bristol Myers Squibb, we work every day to transform patients’ lives through science.
10001+ employees
H1B Sponsorship
Bristol Myers Squibb has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
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Trends of Total Sponsorships
2025 (247)
2024 (278)
2023 (231)
2022 (180)
2021 (181)
2020 (169)
Funding
Current Stage
Public CompanyTotal Funding
$29.32BKey Investors
Venrock
2025-11-05Post Ipo Debt· $5.74B
2024-02-14Post Ipo Debt· $13B
2023-10-30Post Ipo Debt· $4.5B
Leadership Team
Charles Bancroft
CFO
Cristian Massacesi
Executive Vice President, Chief Medical Officer and Head of Development
Recent News
2026-01-09
2026-01-08
2026-01-07
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