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Vertex · 3 weeks ago

Vertex Summer 2026 Intern, Preclinical Modeling and Simulation, DMPK

Boston, MA

Internship

Hybrid

Intern

$26/hr - $35/hr

2+ years exp

Start in 2026 Spring

Vertex is a global biotechnology company that invests in scientific innovation, and they are seeking a Summer 2026 Intern for their Preclinical Modeling and Simulation team. The intern will work on developing mechanistic and systems-based models of diseases for translational research purposes, gaining meaningful experience in Drug Metabolism Pharmacokinetics functional areas.

Computer Software

No H1B

Responsibilities

Develop and implement quantitative systems pharmacology (QSP) models of relevant diseases in collaboration with the pM&S team

Source modeling techniques and approaches from literature sources or design novel models as necessary to address questions and inform decision making across programs

Collect relevant data from published sources as necessary for model calibration

Present and discuss research progress with the pM&S team, DMPK, and other stakeholders as appropriate

Qualification

MatlabPythonROrdinary differential equationsQuantitative systems pharmacologyPharmacokineticsData visualizationCollaborationCommunication

Required

Enrolled in a graduate program, majoring in Applied Mathematics, Computational Biology, Pharmaceutical Sciences, Chemical Engineering, or a related field of study

Significant experience (2-4 years minimum) using a programming language such as Matlab, Python, R, or Julia to numerically solve systems of ordinary differential equations is required for this position

Experience designing and implementing ordinary differential equation-based models of biological systems, including parameter optimization using time-series data

Experience importing, processing, and visualizing data using one of the programming languages listed above

History of publication and/or conference presentations in mathematical biology, quantitative pharmacology, or QSP

Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization

You must be enrolled in an advanced degree program if graduating before August 2026

You must be available to work full-time, 40 hours per week from May – August 2026

Preferred

Knowledge of pharmacokinetics (PK), pharmacokinetic-pharmacynamic (PKPD) modeling, QSP, population pharmacokinetics (popPK), or graduate coursework in applied mathematics is desirable but not required

Knowledge of modeling softwares commonly used in the pharmaceutical industry such as Phoenix WinNonlin, SimBiology, SimCyp, or MonolixSuite is desirable but not required

Expertise in at least one specific disease area is desirable but not required