Regeneron · 2 weeks ago
Senior Principal Scientist AI/ML Antibody Design and Engineering
Tarrytown, NY
Full-time
Onsite
Senior Level, Lead/Staff
$150K/yr - $246K/yr
7+ years expRegeneron is seeking a Senior Principal Scientist in AI/ML to lead the development of next-generation antibody therapeutics. This role involves building AI-driven platforms for therapeutic discovery and collaborating with various scientists to shape strategy and deliver novel therapeutics.
BiopharmaBiotechnologyPharmaceutical
Responsibilities
Develop novel AI and machine learning tools to enable de novo antibody discovery with unique properties and in silico co-optimization of affinity, expression, stability and PK/half-life
Apply deep learning and generative AI techniques to train/enhance LLM or other relevant language models using internal datasets
Use in silico protein/antibody engineering design tools such as Rosetta to drive for structure-based design and engineering
Collaborate and support scientists from antibody engineering, therapeutic areas and other tech centers to deliver novel molecular entities to our pipeline
Serve as an expert in computational biologic design to keep up with the latest advancements in AI, machine learning, and protein engineering fields
Maintain data records and present to cross-functional teams
Qualification
Required
PhD in Computational Biology, Bioinformatics, Computer Science, Structural Biology or a related field
7-10 years of relevant experience
Proficiency in programming languages such as Python, R and C++
Strong track record of innovation and research accomplishments in developing AI/ML methods
Experience using deep learning tools to successfully solve antibody/protein engineering challenges
Preferred
Experience in using structural modeling and design tools (e.g. Rosetta)
Benefits
Health and wellness programs (including medical, dental, vision, life, and disability insurance)
Fitness centers
401(k) company match
Family support benefits
Equity awards
Annual bonuses
Paid time off
Paid leaves (e.g., military and parental leave)
Company
Regeneron
Regeneron Pharmaceuticals specializes in the discovery, development, and commercialization of innovative medicines.
10001+ employees
H1B Sponsorship
Regeneron has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (157)
2024 (128)
2023 (128)
2022 (137)
2021 (104)
2020 (122)
Funding
Current Stage
Public CompanyTotal Funding
$15.93MKey Investors
U.S. Department of Health & Human Services
2024-07-11Post Ipo Equity· $2.03M
2023-10-18Post Ipo Equity· $5M
2016-08-22Post Ipo Equity· $8.9M
Leadership Team
Aris Baras
Senior Vice President, Regeneron Pharmaceuticals, General Manager, Regeneron Genetics Center
Bari Kowal
Senior Vice President, Head Development Operations & Portfolio Management
Recent News
2026-01-09
2026-01-08
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