Maze Therapeutics · 3 days ago
Senior Scientist I, Computational Biology
South San Francisco, CA
Full-time
Hybrid
Mid, Senior Level
$178K/yr - $215K/yr
4+ years expMaze Therapeutics is a clinical-stage biopharmaceutical company focused on developing novel precision medicines through human genetics. They are seeking a Senior Scientist in Computational Biology to enhance their Computational Biology capabilities, drive innovation in biological research, and lead multiomics analysis to support drug discovery efforts.
BiopharmaBiotechnologyGeneticsTherapeutics
Responsibilities
Drive Innovation: You’ll bring fresh ideas and implement cutting-edge computational approaches to accelerate our understanding of biological pathways and genetic effects in human disease
Lead Multiomics Analysis: Conduct comprehensive analyses of internal and external genomics, single cell/nucleus, spatial transcriptomics, proteomics and metabolomics data to drive actionable insights that advance drug discovery and translational programs
Collaborate Across Teams: Partner with Genetics, Functional Genomics, Translational Sciences, and Biology teams to design studies and integrate computational and experimental data
Build Pipelines: Design, implement, and maintain robust, reproducible workflows to address complex biological challenges, such as characterizing disease-associated genetic variants and understanding drug effects on biological pathways
Qualification
Required
PhD in Computational Biology, Human Genetics, Bioinformatics or related field, with 4+ years in computational biology or drug development
Hands-on expertise analyzing and interpreting data from RNA-seq, single cell/single-nucleus technologies, spatial transcriptomics, long read RNA-seq, and DRUG-Seq (or similar)
Proven ability to build scalable, reproducible pipelines and analyzing single cell/nucleus data to answer mechanism of action questions
Familiarity with machine learning methods applied to omics drug-discovery, with practical experience in selecting appropriate models and validating results
A track record of making impactful contributions to early- and late-stage research programs, including refining computational workflows, developing new methods, and delivering analyses that inform decisions
Understanding of molecular biology techniques and assays used to generate transcriptomics data
Strong communication skills and proven ability to collaborate effectively with cross-functional teams
Preferred
industry experience preferred
Benefits
Competitive medical, dental, and vision insurance
Mental health offerings
Equity incentive plan
401(k) program with employer match
Generous holiday and PTO policy
Company
Maze Therapeutics
Maze Therapeutics is a biotechnology company that develops precision medicines for renal, cardiovascular, and metabolic diseases.
51-200 employees
H1B Sponsorship
Maze Therapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2024 (3)
2023 (2)
2022 (5)
2021 (3)
2020 (1)
Funding
Current Stage
Public CompanyTotal Funding
$646MKey Investors
Matrix Capital ManagementCity Hill Ventures
2025-09-11Post Ipo Equity· $150M
2025-01-31IPO
2024-12-03Series D· $115M
Leadership Team
Jason Coloma
Chief Executive Officer
Misbah Tahir
Chief Financial Officer
Recent News
2026-01-06
Maze Therapeutics, Inc.
2025-11-09
StreetInsider.com
2025-11-07
Company data provided by crunchbase