Mass General Brigham · 3 weeks ago
Postdoc/Research Fellow AI-Driven Computational Biology for CNS Drug Discovery and Delivery
Boston-MA
Full-time
Onsite
Senior LevelMass General Brigham is a not-for-profit organization that supports patient care, research, teaching, and community service. They are seeking a highly motivated Postdoctoral Fellow to lead computational efforts in AI-accelerated drug discovery for neurological diseases, utilizing cutting-edge machine learning methods to analyze multimodal datasets and identify therapeutic targets. This role involves interdisciplinary research and collaboration with experimental teams to develop new strategies for tackling neurodegeneration.
Health CareHome Health CareMedical
Responsibilities
Integrate multimodal data and develop and train AI foundation models on large-scale biological datasets for predictive modeling of cellular responses, target identification, and drug candidate identification
Apply generative and sequence-based ML models to design, model, and optimize binding peptides
Analyze high throughput screens and biological datasets to inform in silico predictions
Qualification
Required
PhD in Computational Biology, Bioinformatics, Machine Learning, Computer Science, Statistics, or a related field (recently completed or near completion)
Strong publication record demonstrating expertise in ML applied to biology
Expertise in Python; experience with deep learning frameworks (PyTorch/TensorFlow); single-cell genomics analysis (Seurat, Scanpy, scVI, etc.); and perturbation modeling (e.g., GEARS, scGen)
Excellent organizational, communication, and teamwork abilities in a fast-paced research environment
Interest in translational impact
Preferred
Experience with biological foundation models (e.g., scGPT, Geneformer, scBERT); generative AI for sequences/proteins/peptides (e.g., RFdiffusion variants); cheminformatics tools (e.g., RDKit, PubChem querying); active learning/uncertainty quantification; pipeline automation (e.g., custom scripts or Airflow); integration of public resources (e.g., OpenTargets, ChEMBL); or basic computational ADMET/pharmacokinetics assessment
Background in neurodegenerative disease
Wet lab skills in molecular and cellular biology, nanotechnology, and pharmacology
Company
Mass General Brigham
Mass General Brigham specializes in providing medical treatments and health diagnostics services.
Founded in 1994
10001+ employees
H1B Sponsorship
Mass General Brigham has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (77)
2024 (61)
2023 (93)
2022 (70)
2021 (80)
2020 (29)
Funding
Current Stage
Late StageLeadership Team
E
Erin Flanigan
SVP, Human Resources, Community, Specialty Hospital Division
O’Neil A. Britton
Chief Integration Officer, Executive Vice President
Recent News
2026-01-19
2026-01-17
2026-01-17
Company data provided by crunchbase