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Flagship Pioneering · 6 hours ago

Scientist, LNP Formulations

Cambridge, MA

Full-time

Onsite

Mid, Senior Level

$100K/yr - $143K/yr

Flagship Pioneering is a privately held, early-stage biotechnology company developing innovative gene therapies. They are seeking an experienced Lipid Nanoparticle (LNP) Formulation Scientist to design, execute, and analyze formulation experiments aimed at innovating next-generation LNP formulations for nucleic acid delivery.

FinanceFinancial ServicesVenture Capital

H1B Sponsor Likely

Responsibilities

Design, execute, and analyze DOE-based formulation experiments to develop and optimize novel LNP formulations

Lead formulation innovation efforts, including lipid selection, composition optimization, and process parameter evaluation

Perform LNP screening and characterization, including size, PDI, encapsulation efficiency, stability, and performance metrics

Apply strong analytical and statistical approaches to interpret complex datasets and guide formulation decisions

Collaborate closely with cross-functional teams (biology, analytics, process development, and project management) to advance programs

Maintain thorough experimental documentation and clearly communicate results and recommendations to stakeholders

Contribute to troubleshooting formulation challenges and continuously improve experimental workflows

Support scale-up considerations and technology transfer as needed

Qualification

LNP formulationsDOE methodologiesAnalytical techniquesLipid-based delivery systemsFormulation science principlesProblem-solving skillsCommunication skillsTeam-oriented

Required

PhD or MS in Chemistry, Pharmaceutical Sciences, Chemical Engineering, Materials Science, or a related field

Strong hands-on experience with LNP formulations, including formulation development and optimization

Demonstrated expertise in DOE methodologies and statistical experimental design

Extensive experience with LNP screening and analytical techniques (e.g., DLS, encapsulation assays, stability studies, physicochemical characterization)

Deep understanding of lipid-based delivery systems and formulation science principles

Proven ability to work effectively in a team-oriented, fast-paced environment

Strong problem-solving skills and ability to manage multiple priorities simultaneously

Strong communication skills for presenting data and influencing technical decisions

Benefits

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Company

Flagship Pioneering

Glassdoor3.3

Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.

Founded in 2000

Cambridge, Massachusetts, USA

501-1000 employees

http://flagshippioneering.com

H1B Sponsorship

Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

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Trends of Total Sponsorships

2025 (8)

2024 (4)

2023 (4)

2022 (4)

2021 (1)