Twist Bioscience · 1 day ago
Manager, Antibody Characterization
USA - Portland, OR
Full-time
Onsite
Senior Level
5+ years expTwist Bioscience is seeking a highly motivated and enthusiastic Manager, Antibody Characterization to join their dynamic Operations Team. The role involves managing and mentoring production team members while overseeing antibody characterization experiments and driving operational excellence through continuous process improvement initiatives.
B2BBiotechnologyChemicalHealth CareLife Science
Responsibilities
Manage, train, and mentor production team members, fostering a collaborative and high-performing laboratory environment
Overseeing, running, and troubleshooting antibody characterization experiments using advanced analytical techniques (e.g. BLI and SPR) in a variety of formats to evaluate binding kinetics, ligand blocking, and binning
Act as the primary point of contact for shift Manufacturing Associates and Specialists, ensuring the team adheres to the plan of record
Provide guidance, oversee priority decisions, and lead troubleshooting efforts for production issues as they arise
Establish and track Key Performance Indicators (KPIs) to drive production efficiency and meet department goals
Model capacity and recommend high-throughput workflow options and staffing plans based on demand forecasts
Drive operational excellence by identifying and implementing Continuous Process Improvement (CPI) initiatives to increase capacity, reduce Turnaround Time (TAT), and lower Cost of Goods Sold (COGS)
Lead complex technical investigations and risk assessments related to processes, including resolving customer incidents
Maintain thorough, accurate, and detailed documentation of all work in batch records, databases, or other approved formats, including problems and deviations
Develop and revise Standard Operating Procedures (SOPs), work instructions, and training documents for the characterization of proteins/antibodies
Ensure the team operates in compliance with necessary quality standards
Collaborate with internal and external customers on protein production projects
Work closely with the Director and support functions to evaluate opportunities for product line improvements, contributing to Twist's strategic vision
Lead cross-functional projects, including running recurring status meetings and managing assignments across teams in the US, Europe, and Asia
Qualification
Required
B.S. or M.S. degree in Biology, Biochemistry, Immunology, Process Engineering, or a related field
5+ years of experience in the biotech/pharmaceutical industry, preferably involving the characterization of diagnostic and/or therapeutic antibodies
Strong understanding of antibody discovery, preferably focusing on assay development and protein characterization
A proven track record of successfully developing and manufacturing protein-based commercial products
Demonstrated scientific leadership, mentoring, and organizational skills in managing direct reports and overseeing external collaborations (e.g., CROs)
Deep expertise in basic synthetic/molecular biology skills, including Mammalian Cell Culturing, Transfection, Buffer Exchange, and molecular biology workflows
Excellent project management skills: proficient with timeline development, project tracking, and the ability to efficiently manage and prioritize multiple projects
Exceptional attention to detail, organizational, and record-keeping skills
Preferred
Previous experience with BLI, SPR, and ELISA strongly preferred
Familiarity with PLM, ERP, and MES management systems is a plus
Company
Twist Bioscience
Twist Bioscience is a biotechnology company that offers synthetic DNA solutions, gene synthesis, and variant libraries.
501-1000 employees
H1B Sponsorship
Twist Bioscience has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (18)
2024 (14)
2023 (22)
2022 (19)
2021 (4)
2020 (6)
Funding
Current Stage
Public CompanyTotal Funding
$553.11MKey Investors
Capital World InvestorsBiomatics Capital PartnersIllumina
2022-02-09Post Ipo Equity· $250M
2020-01-27Post Ipo Equity· $50M
2018-10-30IPO
Leadership Team
Emily Leproust
CEO
Siyuan Chen
Chief Technology Officer
Recent News
2025-12-30
2025-12-24
Company data provided by crunchbase