Scientist, Disease Modeling and Phenotyping jobs in United States
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Synapticure · 1 month ago

Scientist, Disease Modeling and Phenotyping

positionPhiladelphia, PA
timeFull-time
remoteOnsite
seniorityMid, Senior Level
money$90K/yr - $100K/yr

SynaptiCure Inc. is a patient and caregiver-founded company dedicated to transforming the lives of individuals with neurodegenerative diseases. They are seeking a Scientist in Disease Modeling and Phenotyping to develop high-throughput iPSC-based cell models and apply phenotypic screening approaches to advance diagnostics and therapeutics for ALS and FTD.

Health CareMedicalNeuroscienceWellness

Responsibilities

Design and execute phenotypic screening protocols for complex, cell-based assays using high-content imaging and transcriptomic readouts
Conduct hands-on wet lab work, including iPSC culture, differentiation, assay development, and imaging
Analyze and interpret multi-dimensional datasets including image-based screens and RNA-seq data
Collaborate cross-functionally to ensure data quality, reproducibility, and relevance to patient biology
Troubleshoot experimental workflows, including cell-line scale-up, instrument scheduling, and protocol optimization
Lead cellular screens at scale and contribute to the selection and onboarding of new technologies and methodologies
Ensure laboratory SOPs are followed and participate in lab operations, including inventory and process standardization
Maintain awareness of cutting edge disease-relevant and stem-cell modeling publications

Qualification

IPSC culturePhenotypic screeningTranscriptomic analysisHigh-content imagingBiochemical assaysWet lab techniquesScientific communicationProject managementCollaboration skillsAdaptability

Required

PhD (or equivalent experience) in neuroscience, biomedical sciences, bioengineering, computational biology, or a related discipline
Strong experience with wet lab techniques, particularly iPSC culture, differentiation, imaging, qPCR, and protein assays
Interest or experience in basic computational biology or high-content data analysis
Excellent documentation, scientific communication, and project management skills
Ability to collaborate in a multidisciplinary environment and juggle multiple projects at once
Adaptability in a dynamic startup setting with a proactive, solution-oriented mindset

Preferred

Experience with transcriptomic or omics analysis (RNA-seq, single-cell)
Proficiency in microscopy techniques, including immunohistochemistry, 3D imaging, and high-content imaging
Experience in neurodegenerative disease modeling
Familiarity with both 2D and 3D cell culture systems
Knowledge of automation, liquid handling, and/or high-throughput screening platforms

Benefits

Comprehensive medical, dental, and vision coverage.
401(k) plan with employer matching.
Generous paid time off and sick leave.
Professional development support and career growth opportunities.

Company

Synapticure

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We provide neurodegenerative disease patients with expert MDs and 24/7 wrap around care, no matter where you live in the US
dateFounded in 2019
location
Chicago, Illinois, USA
people-size51-200 employees
web-link
https://www.synapticure.com/

Funding

Current Stage
Growth Stage
Total Funding
$78.25M
Key Investors
B CapitalGoogle Ventures
2024-11-19Series A· $25M
2024-09-24Series Unknown· $40.15M
2023-01-09Seed· $7.1M

Leadership Team

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Sarahjane Sacchetti
Advisor
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