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Northeastern University · 2 weeks ago

Sr Lab Technician, Mass Spectrometry Facility

Boston, MA

Full-time

Onsite

Mid, Senior Level

$23.02/hr - $31.66/hr

1+ years exp

Northeastern University is seeking a Sr Lab Technician for their shared Research Mass Spectrometry Facility within the Department of Chemistry and Chemical Biology. The role involves operating and maintaining chromatography and mass spectrometry equipment, performing sample preparation, conducting data analysis, and training users, while also managing laboratory safety and administrative duties.

Education

Growth Opportunities

No H1B

Responsibilities

Equipment Operation, Maintenance, and Training – The Sr Lab Technician of the Facility will be responsible for operating the Facility equipment and preparing samples. Additionally, the Sr Lab Technician will be engaged in troubleshooting, maintaining, and operating liquid chromatographs, mass spectrometers, and other associated equipment used in the analysis of biological and chemical samples, including biological fluids, tissues, cells, and bacteria. This person will also be responsible for training students and prospective users who will operate mass spectrometers frequently

Method Development and Researcher Support – The Sr Lab Technician will assist the Associate Director in developing new methods, particularly in single-cell proteomics and small molecule quantification, and will contribute to equipment and training proposals

Laboratory Management of Space, Health, and Safety Matters – The Sr Lab Technician will work with the Associate Director of the Facility and the College Safety Officer to maintain a safe working environment and to address identified laboratory safety and facilities issues immediately

Supply Management and Equipment Service Oversight – The Sr Lab Technician will help manage a consumables budget, monitoring spending and initiating purchases on behalf of the laboratory. The Sr Lab Technician will also assist in managing instrument service contracts

Qualification

LC-MS/MSProtein characterizationMethod developmentProteomicsMetabolomicsData processingTraining skillsRPythonCommunication skillsOrganizational skills

Required

M.S in Chemistry, Biochemistry, Analytical Chemistry, or related field, or Bachelor's degree with 1-5 years of relevant post-graduate experience required

Demonstrated hands-on proficiency with LC-MS/MS for protein and peptide identification and characterization, and small molecule analysis

Experience with protein sample preparation, small molecule extraction, and data processing (using open source software, such as MaxQuant, Perseus, and Skyline) is also required

Preferred

Solid understanding of proteomics, metabolomics, protein chemistry, and protein characterization methods

Experience with protein identification and characterization of post-translational modifications, including in-depth knowledge of Orbitraps, triple quadrupole, and TimsTOF instrument operation and maintenance, data interpretation, and background literature

Interest or expertise in single-cell and limited sample proteomics is highly desirable

Knowledge of R or Python coding would be desirable but not necessary