Apply on Employer Site

Deep Genomics · 3 weeks ago

Senior Research Associate, Platform Technology

Cambridge, MA

Full-time

Onsite

Mid, Senior Level

3+ years exp

Deep Genomics is at the forefront of integrating artificial intelligence and complex biology to transform drug discovery. They are seeking a Senior Research Associate to join their Platform Technology team, where the role involves designing and optimizing genomics-based assays to support RNA therapeutics discovery.

Artificial Intelligence (AI)BiotechnologyGeneticsTherapeutics

Responsibilities

Design, execute, and optimize high-throughput genomics assays, including NGS workflows, targeted sequencing, RNA-seq, and high-content gene expression readouts, to evaluate RNA therapeutic candidates

Sequence prepared libraries independently using instruments such as the Illumina NextSeq, including run setup, instrument operation, and routine troubleshooting

Troubleshoot library prep, QC metrics, and workflow bottlenecks to ensure consistently high-quality datasets for computational analysis

Implement automated workflows using liquid handlers (e.g., Hamilton STAR, Agilent Bravo, Beckman Echo) to scale discovery and screening activities

Perform a broad range of molecular biology techniques including PCR, qPCR/ddPCR, and nucleic acid extractions on a variety of cell types and tissues

Clearly document experimental plans, results, SOPs, troubleshooting steps, and data within an electronic lab notebook (ELN)

Present experimental findings and assay performance updates to project teams and collaborators

Qualification

NGS library preparationGenomics-based assaysMolecular biology techniquesRNA therapeutic modalitiesLiquid handling platformsHigh-throughput screeningCommunicationOrganizational skillsDocumentation skills

Required

BS or MS in Molecular Biology, Genetics, Genomics, Biotechnology, Biochemistry, or related discipline with 3–6 years of relevant industry experience

Strong understanding of molecular and cell biology principles

Experience with NGS library preparation, including amplicon-seq, bulk RNA-seq, targeted panels, or single-cell sequencing

Experience extracting RNA/DNA from cells and animal tissues

Demonstrated proficiency in designing and executing genomics-based or molecular assays

Excellent communication, organizational, and documentation skills

Ability to prioritize and drive work independently in a fast-paced research environment

Preferred

Proficiency with specific liquid handling platforms such as Hamilton STAR, Agilent Bravo, or Beckman Echo

Familiarity with RNA therapeutic modalities (ADAR editing, ASOs, siRNAs, mRNA)

Hands-on experience growing, maintaining, and transfecting mammalian cells

Prior experience in a biotechnology, pharmaceutical, or platform-driven discovery environment and demonstrated ability to collaborate within a highly cross-functional and multidisciplinary team