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Flagship Pioneering · 2 weeks ago

Senior Scientist I/II, Chemistry & Formulations

Cambridge, MA USA

Full-time

Onsite

Mid, Senior Level

$126K/yr - $182K/yr

5+ years exp

Flagship Pioneering is a biotechnology origination company dedicated to developing life sciences ventures. The role seeks an experienced formulations chemist to lead the design and implementation of a high-throughput chemical formulation and testing pipeline, focusing on manufacturing chemical mixtures and characterizing their properties.

FinanceFinancial ServicesVenture Capital

H1B Sponsor Likely

Responsibilities

Manufacturing formulations

Design and implement a scalable high-throughput workflow for generating diverse chemical mixtures

Rigorously catalog known formulations for comparison to newly developed and untested formulations

Establish automated liquid handling, dosing, and mixing protocols to ensure reproducibility and throughput

Develop standard operating procedures (SOPs) for safe handling, storage, and disposal of raw materials and formulations

Collaborate with upstream ML lead on formulation design workflows that maximize our canvassing of chemical property space and support the generation of high-quality, broad-coverage training data

Characterizing formulation properties

Assess viscosity, solubility, and other physiochemical features under different hydration and temperature conditions

Apply spectroscopy (UV-Vis, IR, fluorescence) to quantify molecular interactions and stability

Use calorimetry and thermal gravimetric analysis to measure thermodynamic and thermal stability profiles of formulations

Develop and validate assays to track long-term stability and degradation of formulations

Screening formulation-cargo interactions

Design assays to evaluate compatibility of formulations with diverse small molecules, peptides, proteins, and nucleic acids

Measure cargo protection and stability (e.g., aggregation, precipitation, degradation) under varied conditions

Integrate biophysical characterization methods (DLS, CD, IR, LCMS) to assess cargo–formulation interactions

Qualification

Formulation ChemistryHigh-Throughput ScreeningSpectroscopy TechniquesChemical CharacterizationThermodynamicsData Analysis PipelinesMachine Learning IntegrationScripting SkillsBiomolecule ExperienceTeam CollaborationLeadership ExperienceCommunication Skills

Required

Ph.D. in Organic Chemistry, Physical Chemistry, Chemical Engineering, Materials Science, or a related field + 5 years of experience (including 2 years of industry at minimum). Education may count towards years of experience

Extensive hands-on experience with formulation chemistry, high-throughput chemical screening, or analytical method development

Demonstrated expertise in chemical characterization techniques such as spectroscopy (UV-Vis, IR, NMR, fluorescence), calorimetry (DSC, ITC), and rheology

Proven ability to characterize physicochemical properties of complex mixtures under varying environmental conditions

Strong background in designing and executing high-throughput or automated experimental workflows

Committed team player with the ability to communicate and work collaboratively with ML scientists, lab scientists and operational team members

Preferred

Prior leadership or team management experience

Experience integrating benchtop experimental data into machine learning pipelines or predictive modeling workflows

Strong understanding of thermodynamics, kinetics, and intermolecular interactions in multicomponent systems

Familiarity with high-throughput robotics, automation platforms, or liquid handling systems for screening of solvents and liquids

Knowledge of data analysis pipelines, including scripting skills (e.g., Python, R, MATLAB) for handling large experimental datasets

Exposure to generative AI models for chemical discovery

Experience working with biomolecules and protein chemistry

Familiarity with principles of physical chemistry

Experience in chemistry screening for personal care, nutrition, or aqueous coatings and adhesives

Benefits

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Company

Flagship Pioneering

Glassdoor3.3

Flagship Pioneering is a venture capital firm that invests in life sciences and healthcare companies.

Founded in 2000

Cambridge, Massachusetts, USA

501-1000 employees

http://flagshippioneering.com

H1B Sponsorship

Flagship Pioneering has a track record of offering H1B sponsorships. Please note that this does not guarantee sponsorship for this specific role. Below presents additional info for your reference. (Data Powered by US Department of Labor)

Distribution of Different Job Fields Receiving Sponsorship

Represents job field similar to this job

Trends of Total Sponsorships

2025 (8)

2024 (4)

2023 (4)

2022 (4)

2021 (1)