Work In Biotech · 3 weeks ago
Scientist, Antibody Discovery and Engineering
San Francisco, CA
Full-time
Onsite
Mid, Senior Level
2+ years expWork In Biotech is a stealth-mode biotechnology venture based in San Francisco, seeking a highly motivated Scientist to join their Antibody Discovery and Engineering team. The role involves contributing to the discovery and optimization of therapeutic antibodies using advanced technologies in a fast-paced environment focused on developing next-generation biologics.
Human ResourcesRecruitingStaffing Agency
Responsibilities
Lead VHH and related discovery campaigns using yeast and phage display technologies, including experimental design, execution, and troubleshooting
Perform hands-on antibody discovery workflows, including library construction, panning, output screening, single-clone characterization, and data summarization
Analyze binding kinetics, specificity, and stability of antibody leads using biochemical and biophysical assays such as SPR, BLI, ELISA, and cell-binding studies
Accurately document experiments and maintain electronic lab notebooks (Benchling) in a timely manner
Conduct in-depth data analysis and effectively communicate results in project meetings, ensuring alignment with timelines and goals
Collaborate with cross-functional teams (protein science, biology, and in vivo pharmacology) to optimize antibody properties
Coordinate with CROs on activities related to animal immunization, protein production, and characterization
Performs additional duties as assigned
Qualification
Required
Education: Master's degree in Biology or a related field with 5+ years of experience in antibody discovery, or a Ph.D. with 2+ years of relevant experience
Proven ability to design and apply in vitro antibody discovery display technologies (e.g., phage display, yeast display) for antibody discovery and/or engineering
Strong molecular biology skills, including PCR, DNA/RNA isolation, plasmid preparation, gel extraction, cloning, and Sanger sequencing analysis
Hands-on experience with SPR (Carterra LSA, Biacore) or BLI (Octet, Gator), ELISA and flow cytometry
Demonstrated scientific productivity and independence, with strong problem-solving skills
A strong desire to work in a dynamic startup environment is essential
Comfortable working in an environment involving radiolabeled therapeutics
Preferred
Strong communication skills to work within a multidisciplinary team environment
Experiences leading project from antibody discovery to drug candidate selection
Knowledgeable in recombinant protein production and characterization
Proficiency with bio-tools such as GraphPad Prism, Geneious, FlowJo and Benchling
Demonstrated track record in managing multiple projects and prioritizing tasks to meet schedules and timelines
Excellent written and oral communication skills and the ability to present effectively to teams
Benefits
Competitive compensation package including equity participation
Company
Work In Biotech
Work In Biotech is a job board and recruiting service for biotech startups, offering job listings and an AI-cruiter tool.
2-10 employees
Funding
Current Stage
Early StageLeadership Team
Kelly Burke
Founder and Principal Recruiter
Company data provided by crunchbase