Oxford BioTherapeutics · 2 weeks ago
Associate/Scientist, Protein-Biologic Discovery
San Jose, CA
Full-time
Onsite
Mid, Senior Level
4+ years expOxford BioTherapeutics (OBT) is a dynamic, rapidly-growing biotechnology company focused on oncology therapies. The role involves leading the development of antigen antibodies against novel targets and contributing to the production of recombinant proteins and monoclonal antibodies for Early Discovery and Validation Research.
BiotechnologyGeneticsHealth CareHealth DiagnosticsTherapeutics
Responsibilities
Be a contributor to the discovery and development of antibody therapeutics for oncology and immune oncology for novel targets
Support recombinant protein and bi- and multi-specific antibody discovery plans (immunogen design, assay development, screening, and functional characterization methods)
Support biological discovery through different platforms of protein and antibody discoveries
Responsible various target projects to execute protein production and antibody discovery/optimization in various platforms
Generate target over-expressing cell lines for antibody discovery work
Develop strategies to express, purify, and analyze proteins for novel tumor targets expressed in mammalian cells
Perform purification using AKTA/HPLC systems and maintain equipment
Conduct antibody characterization of antibodies including binding affinity and binding kinetics through Octet/Biacore, epitope binning/mapping, and functional assays
Troubleshoot experimental issues with guidance; contribute to process and assay transfers
Mentor lower-level colleagues and assist in scientific optimization & development
Analyze data, interpret results, identify problems, and develop trouble-shooting plans
Maintain accurate documentation and follow laboratory safety procedures
Knowledge of the biologics drug discovery process and representation of the protein science function at project team meetings
Compliances with data management, laboratory notebook policy, and laboratory safety
Qualification
Required
Ph.D. in biological sciences or related fields with 4+ years of post-Ph.D., or MS with 6+ or BS with 8+ years of experience in biopharma industry or closely related scientific discipline, preferably in a fast-paced startup environment
Experience in molecular biology or/and biochemistry, including gene manipulation, subcloning, expression vector modifications, and protein expressions in HEK & CHO cell systems
Extensive experience in human protein and antibody purification techniques, including affinity chromatography, ion exchange chromatography (HIC), ion exchange chromatography (IEX), and size exclusion chromatography (SEC). Proficiency in operating and troubleshooting modern chromatography hardware and software, such as Cytiva AKTA systems and Agilent HPLC and UPLC
Knowledge of the biologics drug discovery process and representation of the protein science function at project team meetings
Compliances with data management, laboratory notebook policy, and laboratory safety
Preferred
Experience in developing and optimizing recombinant proteins and bi- and multi-specific antibody formats across multiple parameters is preferred
Antibody drug discovery experience for immune oncology in biopharmaceutical industry is a plus
Ability to independently manage projects and deliver results on stringent timelines with high quality is plus
Benefits
Medical, dental and vision insurance for employee and dependents
FSA (Flexible Spending Account)
STD, LTD, Basic Life and AD&D Insurance, Supplemental Life
401(k) Plan
120 hours of Paid Time Off
5 sick days per year
11 public holidays
Employee Referral Bonus Program
Annual bonus program
New hire stock options
Company
Oxford BioTherapeutics
Oxford BioTherapeutics develops medicines for cancer and companion diagnostics for selected antibody programs.
11-50 employees
H1B Sponsorship
Oxford BioTherapeutics has a track record of offering H1B sponsorships. Please note that this does not
guarantee sponsorship for this specific role. Below presents additional info for your
reference. (Data Powered by US Department of Labor)
Distribution of Different Job Fields Receiving Sponsorship
Represents job field similar to this job
Trends of Total Sponsorships
2025 (2)
2020 (1)
Funding
Current Stage
Early StageTotal Funding
$33.22MKey Investors
Calculus CapitalOxford Finance LLCSilicon Valley Bank
2021-01-01Series Unknown
2018-08-03Series Unknown· $2.6M
2017-01-26Debt Financing· $10M
Leadership Team
Abderrahim Fandi, MD PhD
Chief Medical Officer
Joyce B.
Human Resources and Office Business Partner
Recent News
2025-12-15
MarketScreener
2025-12-10
Company data provided by crunchbase