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CHEManager International · 2 hours ago

Senior Scientist I, Cell-free Protein Synthesis

Somerville, MA

Full-time

Onsite

Senior Level, Lead/Staff

$125K/yr - $175K/yr

10+ years exp

Generate:Biomedicines is a therapeutics company pioneering Generative Biology™ to create breakthrough medicines. The Senior Scientist I in Cell-free Protein Synthesis will expand the CFPS platform using synthetic biology and machine learning, optimizing workflows and collaborating with various teams to enhance therapeutic development.

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Responsibilities

Expand Generate's efforts to integrate CFPS into our HTP screening and Cryo-EM workflows

Lead part of the team efforts to optimize CFPS workflows using both experimental tools (strain engineering, synthetic biology, automation, Cryo-EM) and theory (computational analysis, statistics, and ML-guided optimization)

Work with production and analytics teams in the Protein Sciences department to optimize scaled-up workflows and implement characterization of CFPS-produced material

Generate bold, creative, unconventional ideas, and be a point person for intellectual property and patent writing

Strategic experiment planning, data interpretation, summarization, and presentation with minimum supervision are required

Involvement in accelerating the discovery, engineering and characterization of novel biologics in the pipeline programs

Mentor and train scientists throughout the company

Qualification

Cell-Free Protein SynthesisSynthetic BiologyHigh-Throughput ExperimentationCryo-EMData AnalysisProactiveTeam PlayerMentoring

Required

BSc/MSc with 10+ years or PhD+4 years of experience in a relevant science/engineering field (biophysics, biochemistry, physical chemistry, biological engineering, quantitative/synthetic biology, or related discipline)

Demonstrated expertise in implementation, analysis, and optimization of Cell-Free Protein Synthesis systems

Demonstrated experience in laboratory automation and high-throughput experimental design

Highly motivated, proactive and enthusiastic team player demonstrating flexibility and a sense of urgency